대장 종양에서 CD43의 발현에 관한 연구 = Expression of CD43 in Colorectal Adenocarcinoma

다국어 초록 (Multilingual Abstract)

Background : CD43 is a sialoglycoprotein that is highly expressed on most leukocytes, except
on B lymphocytes and dendritic cells. CD43 has been reported to be involved in the adhesion
and apoptosis of lymphocytes. Although the aberrant expression of CD43 antigen in non-lymphoid
tissues has been reported, the expression of the CD43 antigen in gastrointestinal
malignancies is not well studied. Here, we studied the expression of CD43 in colon adenocarcinoma
using the anti-CD43 monoclonal antibody developed in our laboratory. Methods :
Thirty patients who had undergone surgical resection for colorectal carcinoma were recruited.
The expression of CD43 molecule was determined by analyzing the formalin-fixed, paraffinembedded
specimens immunohistochemically using our newly developed anti-CD43 mAb
(K06). The results obtained by the immunohistochemical analysis correlated to the clinicopathological
parameters. Results : The expression of CD43 were found in 20 out of 30 colorectal
carcinoma cases. The expression of CD43 antigen is higher in well differentiated adenocarcinomas
than poorly or moderately differentiated adenocarcinomas. Conclusions : The new anti-
CD43 mAb might be helpful for the detection of the expression of CD43 on colorectal carcinoma
cells. Further studies are required to assess the relationship between the CD43 expression
and the colorectal carcinogenesis.

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