the effect of prostaglandin E2 and cimetidine on acute gastric mucosal lesions produced by topical aspirin(200 mg/kg) plus HCI(150 mM) in the pylorus ligated rats were studied. 16, 16-dimethyl prcstaglandin E2 and cimetidine significantly reduced gast...
the effect of prostaglandin E2 and cimetidine on acute gastric mucosal lesions produced by topical aspirin(200 mg/kg) plus HCI(150 mM) in the pylorus ligated rats were studied. 16, 16-dimethyl prcstaglandin E2 and cimetidine significantly reduced gastric juice secreticn, pH and acid output. A 1so 16, 16-dimethyl prostaglandin E2 and cimetidine significantly reduced acute gastric muicosal lesion although acid was given exogenously so as to negate any antisecretory effect of the drugs studied. We conclude that both 16, 16-dimethyl prostaglandin E2 and cimetidine reduced gastric juice secretion, pH, and acid output and also protect gastric mucosal lesion by some means other than their effect on acid output.