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      Behc¸et 병에서 말초혈액 호중구의 Superoxide anion (O₂^(-)) 생성 능력에 관한 연구 = A Study on the Superoxide Anion(O₂(-)) Generation Activity of the Peripheral Blood Neutrophils in Behc¸et's Disease

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      https://www.riss.kr/link?id=A40022002

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      The present study was carried out to investigate the mechanism of inflammtion and tissue injury in Behcet's disease.
      The generation of O₂(-) was assessed by superoxide dismutase inhibitable cytochromec reduction method. The O₂(-) generation activity was expressed as nanomoles of cytochrome c reduced per 1×10^(6) neutrophils.
      The O₂(-)generation activity of peripheral blood neutrophils of the patients was compared to that of healthy controls, and was analyzed in the respect of clinical severity, exacerbation and improvement, pathergy reaction, and tetracycline treatment for oral ulcer.
      The results were summarized as follows :
      1. The O₂(-) generation activity of neutrophils in Behcet's disease was markedly increased as compared with that of healthy controls.
      2. In the patient group with severe clinical symptoms, exacerbated clinical course and positive pathergy reaction, the O₂(-) generation activity of neutrophils was increased.
      3. The O₂(-) generation activity of neutrophils was markedly decreased in the patient group treated with tetracycline for oral ulcer.
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      The present study was carried out to investigate the mechanism of inflammtion and tissue injury in Behcet's disease. The generation of O₂(-) was assessed by superoxide dismutase inhibitable cytochromec reduction method. The O₂(-) generation activ...

      The present study was carried out to investigate the mechanism of inflammtion and tissue injury in Behcet's disease.
      The generation of O₂(-) was assessed by superoxide dismutase inhibitable cytochromec reduction method. The O₂(-) generation activity was expressed as nanomoles of cytochrome c reduced per 1×10^(6) neutrophils.
      The O₂(-)generation activity of peripheral blood neutrophils of the patients was compared to that of healthy controls, and was analyzed in the respect of clinical severity, exacerbation and improvement, pathergy reaction, and tetracycline treatment for oral ulcer.
      The results were summarized as follows :
      1. The O₂(-) generation activity of neutrophils in Behcet's disease was markedly increased as compared with that of healthy controls.
      2. In the patient group with severe clinical symptoms, exacerbated clinical course and positive pathergy reaction, the O₂(-) generation activity of neutrophils was increased.
      3. The O₂(-) generation activity of neutrophils was markedly decreased in the patient group treated with tetracycline for oral ulcer.

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