기관지천식 환자의 객담내 집먼지진드기 - 특이 IgA 항체의 측정

다국어 초록 (Multilingual Abstract)

To evaulate the possible pathogenetic significance of allergen specific IgA antibody in respiratory secretion from asthmatics, we measured house dust mite(HDM) specific IgA antibody in 3% saline induced sputum from 23 HDM sensitive asthmatics, 4 atopic asthmatics without mite sensitivit.y, 6 non atopic asthmatics, and 13 non atopic, non asthmatic controls (including 6 non atopic healthy controls, 4 patients with chronic bronchitis, and 3 patients with rheumatoid arthritis) by ELISA. We also measured HDM specific IgA antibody in serum and numbers of eosinophils in spu- tum. 1) Levels of HDM specific IgA sntibody in sputum from mite sensitive asthmatics were significantly higher than those from non atopic, non asthmatic controls and non atopic asthmatics(p(0.05). Levels of HDM specific IgA antibody in sputum from atopic asthmatics without mite sensitivity were significantly higher than those from non atopic, non asthmatic controls (p<0.05), however HDM specific IgA/albumin raito was not significantly different between two groups (p> 0.05). 2) The ratio of HDM specific IgA antibody to albumin in sputum was not significantly dif- ferent in mite sensitive asthmatics with sputum eosinophila ( 2 5% of 200 counted leukocytes) and t,hose without sputum eosinophilia (p > 0.05). 3) The ratio of HDM specific IgA to albumin in sputum from asthmatics was higher than that of serum. 4) There was no significant correlation of HDM specific IgA/albumin ratios between serum and sputum (p> 0.05). 5) When comparing sputum and saliva samples from 7 mite sensitive asthmatics, levels of HDM specific IgA antibody in sputum were significantly higher than those in saliva (p<0.05). In conclusion, HDM specific IgA antibody was increased in sputum from HDM sensitive asthmatics, and it might be locaUy produced from bronchial mucosa. To evlauate the pathogenetic sigriificance of allergen specific IgA antibody in respiratory secretion from asthmatics, further studies might be needed.