TBSS(Tract-Based Spatial Statics)를 이용한음주 시작연령에 따른 해마 영역 부위의 신경섬유의 비등방도 측정 = Measurement of the Anisotropy of Nerve Fibers in the Hippocampal Region according to the Drinking beginning Age using TBSS(Tract-Based Spatial Statics)

다국어 초록 (Multilingual Abstract)

Tract-Based Spatial Statics (TBSS) after obtaining the image by examining a diffusion tensor image that can determine the presence or absence of damage to the cerebral white matter and gray matter for middle-aged men aged 30 to 50 with the starting age of drinking as a variable. As a result of measuring and analyzing the FA (fractional anisotropy) value of the brain gray matter region to the hippocampal region nerve fibers, the lower the alcohol start age in all regions, the lower the anisotropy measurement value, but the FA value was statistically significant. . The study results indicated by the FA results measured in this study are that the earlier the drinking start age, the more severe the morphological changes in all neurological and anatomical brain regions in the hippocampal region of the brain gray matter and seriously affect the nerve fiber tissue. It can be said to harm and damage nerve fibers and affect functional morphological variations associated with alcohol.

국문 초록 (Abstract)

음주 시작연령을 변수로 하여 30세 이상 50세 이하의 중장년층 남성을 대상으로 뇌 백질과 회백질의 손상 유무를 파악할 수 있는 확산텐서영상을 검사하여 영상을 획득한 후 Tract-Based Spatial Statics(TBSS)방법으로 뇌 회백질 부위의 해마 영역 부위 신경섬유로의 비등방도 FA(fractional anisotropy)값을 측정 분석한 결과 모든 영역에서 음주 시작연령이 낮을수록 비등방성 측정값이 낮게 관찰되었지만 FA 값은 통계적으로 유의하였다. 본 연구에서 측정한 FA 결과 값이 나타내는 연구결과는 즉, 음주 시작연령이 빠를수록 뇌 회백질의 해마 영역의 모든 신경학적이고 해부학적인 뇌 영역의 세부적인 형태학적 변화와 신경섬유조직에 심각하게 영향을 준다고 할 수 있으며 신경섬유로를 위해 및 손상시키고 알코올과 관련된 기능적 형태학적 변이에 영향을 끼친다고 할 수 있다.

목차 (Table of Contents)

• Ⅰ. INTRODUCTION Ⅱ. MATERIAL AND METHODS Ⅲ. RESULT Ⅳ. DISCUSSION Ⅴ. CONCLUSION Reference

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