주의력결핍 과잉행동장애 아동에서 α-2A 아드레날린 수용체 유전자의 MspI 유전자 다형성에 따른 메칠페니데이트 치료 전후 뇌관류 비교

다국어 초록 (Multilingual Abstract)

Objectives：Dysregulation of the central noradrenergic system may be involved in the pathophysiology of attention-deficit hyperactivity disorder (ADHD). The aim of this study was to examine the differences in pre- and post-treatment cerebral perfusion according to the MspI polymorphisms of the alpha-2A-adrenergic receptor gene (ADRA2A) in children with ADHD.
Methods：Thirty seven drug-naive ADHD children (8.9+1.8 years old, M=32, F=5) were genotyped. Baseline single-photon emission computed tomography (SPECT) and clinical assessments were performed for ADHD children. After treatment with methylphenidate for eight weeks, SPECT and clinical assessment were repeated.
Results：No differences in baseline clinical assessments or cerebral perfusion were observed according to the MspI genotype. However, after treatment, ADHD children with the G/G genotype at the MspI polymorphism showed hyperperfusion in the right cerebellar declive (p=.001, uncorrected) and hypoperfusion in the left lentiform nucleus and left cingulate gyrus (p＜.001 and p=.001, uncorrected), compared to children without the G/G genotype.
Conclusion：Although the results of this study should be interpreted cautiously, they suggest a possible role of the MspI polymorphisms of the ADRA2A gene in methylphenidate-induced changes in cerebral perfusion.

목차 (Table of Contents)

• 서론
• 방법
• 결과
• 고찰
• References

참고문헌 (Reference)

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