Antibodies against GM1 and GD1a are closely associated with acute motor axonal neuropathy (AMAN). Patients simultaneously positive for both anti-GM1 and anti-GD1a antibodies are rare, and their clinical manifestations and prognosis remain unclear. Her...
Antibodies against GM1 and GD1a are closely associated with acute motor axonal neuropathy (AMAN). Patients simultaneously positive for both anti-GM1 and anti-GD1a antibodies are rare, and their clinical manifestations and prognosis remain unclear. Herein we report a 41-year-old male diagnosed with AMAN and acute transverse myelitis who was positive for immunoglobulin M anti-GM1, immunoglobulin G (IgG) anti-GM1, and IgG anti-GD1a antibodies. He experienced rapid progression of motor weakness to near quadriplegia within a few days, followed by substantial improvement over 6 months after initiation of steroid treatment, resulting in return of most activities of daily living.