Distribution of the Immunoreactivity for Glycoprotein M6B in the Neurogenic Niche and Reactive Glia in the Injury Penumbra Following Traumatic Brain Injury in Mice

다국어 초록 (Multilingual Abstract)

The location and morphology of astrocytes are known to contribute to their diversity, and this diversity is often associated withtheir selective functions. However, molecular markers for astrocyte subtypes are largely unknown. In this study, we found that theimmunoreactivity for glycoprotein GPM6B (M6B-IR) is preferentially expressed in the astrocytes associated with ventricles orneurogenic regions of the adult mouse brain. In particular, M6B-IR in the neurogenic niche was confined to glial fibrillary acidicprotein- or nestin-expressing neural stem cells. Furthermore, in the injury penumbra, reactive astrocytes expressing nestin alsoexhibited strong M6B-IR. These results reveal that GPM6B is a potential molecular marker for a subset of astrocytes, as well as forthe injury-dependent activation of astrocytes.

참고문헌 (Reference)

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