S-2 Clinical Characteristics of Peptic Ulcer Perforation in Korea = S-2 Clinical Characteristics of Peptic Ulcer Perforation in Korea

다국어 초록 (Multilingual Abstract)

Background:?The incidence of complications of peptic ulcer has not been decreasing and only a few data is available about epidemiological characteristics and associated risk factors of benign perforated peptic ulcer (PPU). Methods:?We retrospectively reviewed 396 patients who were histologically diagnosed with benign perforated peptic ulcer disease from January 2010 through December 2015 at Hallym university-affiliated hospitals including the Chuncheon, Kangdong, Dongtan, Hangang, Kangnam and Hallym University Sacred Heart Hospital. Results:?A total of 396 patients (43.7% in gastric ulcer and 56.3% in duodenal ulcer) with PPU were identified. Among 174 (43.9%) patients who were examined for Helicobacter pylori (H. pylori) infection, 73 (42.0%) patients were positive for H. pylori, 21 (12.1%) were on nonsteroidal anti-inflammatory drugs (NSAIDs) therapy, and the remaining 80 (46%) patients were neither infected of H. pylori nor treated by any kinds of NSAIDs. In NSAIDs users, the mean age was higher (66.7 years) and the proportion of patients with any comorbidities (66.7%) and perforation more than 1 cm in diameter (64.7%) was higher than that of H. pylori (＋) and Non-H. pylori, non-NSAID group. In the non-H. pylori, non-NSAID group, the proportion of alcohol consumption (58.8%) and/or smoking habits (65.0%) were higher than other groups with marginal significance. 36 (9.1%) patients experienced postoperative complication, and 3 (0.8%) patients died during hospitalization because of acute respiratory distress syndrome or uncontrolled sepsis. Conclusions:?Almost half of the patients with PPU were included in the non-H. pylori, non-NSAID group. Smoking and alcohol consumption tend to be associated with Non-H. pylori, non-NSAID PPU.