성빈센트병원에 입원한 암 환자에서 피로 유병율 = The prevalence of fatigue in cancer patients at St. Vincent`s hospital

다국어 초록 (Multilingual Abstract)

Background: Fatigue is one of the most common problems in terminally ill cancer patients in North America and Europe. However, fatigue has been almost neglected by health care professionals and even by patients and their families in Korea. We studied the prevalence and characteristics of fatigue in cancer patients who were admitted to St. Vincent`s Hospital. Methods: Ninety-three competent patients who were admitted to the cancer or hospice ward were asked to answer whether they had fatigue or other cancer related problems on three occasions on April 4, 11 and 18, 2006. Additional demographic data were also analyzed. Results: Thirty (32.3%) of the 93 patients responded that they had fatigue. The response was from 20/71 male and 10/22 female patients. The median age was 66 years (range 35-84 years). The ECOG performance status was 1, 2 and 3 in 10, 12 and 8 patients respectively. Lung cancer (21 patients) was the most common malignancy followed by gastric cancer, colon cancer and other cancers. Fourteen patients received chemotherapy, 13 patients received supportive care and 3 patients received chemoradiotherapy. Other cancer related symptoms were pain (17 patients), anorexia (16 patients), sleep disturbance (14 patients), and anxiety and depression. The severity of fatigue was grade 1, 2, 3 in 17, 6 and 7 patients respectively. Twenty-eight patients had anemia based on the WHO scale, and there was no relationship between the grade of fatigue and hemoglobin level. Conclusions: Fatigue was a frequent symptom in cancer patients (32%) and more frequent in female patients (45%). More attention needs to be paid to the significance of fatigue in cancer patients.(Korean J Med 73:512-518, 2007)

참고문헌 (Reference)

1 정은자, "항암 화학요법 환자의 피로 관련 요인" 한국호스피스완화의료학회 7 (7): 179-188, 2004

2 권영은, "항암 화학요법 암 환자의 피로와 삶의 질과의 관계 연구" 11 : 820-830, 1999

3 양영희, "위암환자의 항암 화학요법에 따른 피로와 삶의 질 변화 양상" 한국간호과학회 32 (32): 482-491, 2002

4 양영희, "방사선 치료를 받는 암환자의 피로, 삶의 질 및 신체 증상의 변화 양상" 한국간호과학회 33 (33): 562-569, 2003

5 심병용, "말기암 환자에서의 하지부종" 한국호스피스완화의료학회 8 (8): 152-155, 2005

6 Piper BF, "The revised Piper Fatigue Scale: psychometric evaluation in women with breast cancer" 25 : 677-684, 1998

7 Mendoza TR, "The rapid assessment of fatigue severity in cancer patients: use of the Brief Fatigue Inventory" 85 : 1186-1196, 1999

8 Schwartz AL, "The Schwartz Cancer Fatigue Scale: testing reliability and validity" 25 : 711-717, 1998

9 Chang VT, "Symptom and quality of life survey of medical oncology patients at a Veterans Affairs Medical Center" 88 : 1175-1183, 2000

10 Kaye J, "Sleep patterns in patients with cancer and patients with cardiac disease" 114 : 107-113, 1983

11 Porock D, "Nutritional, functional, and emotional characteristics related to fatigue in patients during and after biochemotherapy" 32 : 661-667, 2005

12 Mock V, "NCCN practice guidelines for cancer-related fatigue" 14 : 151-161, 2000

13 Hwang SS, "Multidimensional independent predictors of cancer-related fatigue" 26 : 604-614, 2003

14 Hann DM, "Measurement of fatigue in cancer patients: further validation of the Fatigue Symptom Inventory" 9 : 847-854, 2000

15 Curt GA, "Impact of cancer-related fatigue on the lives of patients: new findings from the fatigue coalition" 5 : 353-360, 2000

16 Visser MR, "How response shift may affect the measurement of change in fatigue" 20 : 12-18, 2000

17 Visser MR, "Fatigue, depression and quality of life in cancer patients: how are they related?" 6 : 101-108, 1998

18 Jacobsen PB, "Fatigue in women receiving adjuvant chemotherapy for breast cancer: characteristics, course, and correlates" 18 : 233-242, 1999

19 Pater JL, "Fatigue in patients with cancer: results with National Cancer Institute of Canada Clinical Trials Group Studies Employing the EORTC QLQ-C30" 5 : 410-413, 1997

20 Stone P, "Fatigue in patients with cancer" 34 : 1670-1676, 1998

21 Nail LM, "Fatigue in patients with cancer" 29 : 537-, 2002

22 Cella D, "Fatigue in cancer patients compared with fatigue in the general United States population" 94 : 528-538, 2002

23 Okuyama T, "Factors correlated with fatigue in disease-free breast cancer patients: application of the Cancer Fatigue Scale" 8 : 215-222, 2000

24 Mast ME, "Correlates of fatigue in survivors of breast cancer" 21 : 136-142, 1998

25 Maughan TS, "Comparison of survival, palliation, and quality of life with three chemotherapy regimens in metastatic colorectal cancer: a multicentre randomised trial" 359 : 1555-1563, 2002

26 National Cancer Institute, "Common terminology criteria for adverse events v3.0"

27 Malone M, "Assessment of the impact of cancer on work, recreation, home, management and sleep using a general health status measure" 87 : 386-389, 1994

28 Harper P, "Anaemia of cancer: impact on patient fatigue and long-term outcome" 69 (69): 2-7, 2005