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      기도 알레르기 생쥐모델에서의 IL-18 발현에 대한 스테로이드의 효과 = Effects of Corticosteroid on Expression of IL-18 in the Airway Mucosa of Allergic Rhinitis Mouse Model

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      https://www.riss.kr/link?id=A104591553

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      Background:This study aimed to investigate the release and response of IL-18 to steroid treatment in the allergic rhinitis
      (AR) mouse model. Materials and Methods:BALB/c mice were sensitized systematically using an intraperitoneal ovalbumin
      (OVA) injection and locally by OVA inhalation. The steroid treatment group had an intraperitoneal dexamethasone
      injection. Symptom scores, eosinophil counts in nasal septal mucosa, and IL-18 concentrations in nasal and lung lavage fluid
      were analyzed. Results:The symptom scores and eosinophil counts of the negative control and steroid treatment groups
      were significantly lower than those of the positive control group (p<.01). Meanwhile IL-18 concentrations of nasal lavage
      fluid of the three groups were not significantly different (56.68±9.57, 63.39±8.93, and 64.47±6.83 pg/mL, repectively).
      IL-18 concentration of lung lavage fluid was significantly different between the positive control and steroid treatment groups
      (430.75±154.54 and 69.94±14.26pg/mL respectively, p=.028). Conclusion:In this study, IL-18 concentration increased
      not in the nasal lavage fluid but in the lung lavage fluid in AR mouse model. The increased IL-18 concentration decreased
      after the steroid therapy. This result suggests that the role of IL-18 in the pathogenesis of AR may be different from that of asthma.
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      Background:This study aimed to investigate the release and response of IL-18 to steroid treatment in the allergic rhinitis (AR) mouse model. Materials and Methods:BALB/c mice were sensitized systematically using an intraperitoneal ovalbumin (OVA) ...

      Background:This study aimed to investigate the release and response of IL-18 to steroid treatment in the allergic rhinitis
      (AR) mouse model. Materials and Methods:BALB/c mice were sensitized systematically using an intraperitoneal ovalbumin
      (OVA) injection and locally by OVA inhalation. The steroid treatment group had an intraperitoneal dexamethasone
      injection. Symptom scores, eosinophil counts in nasal septal mucosa, and IL-18 concentrations in nasal and lung lavage fluid
      were analyzed. Results:The symptom scores and eosinophil counts of the negative control and steroid treatment groups
      were significantly lower than those of the positive control group (p<.01). Meanwhile IL-18 concentrations of nasal lavage
      fluid of the three groups were not significantly different (56.68±9.57, 63.39±8.93, and 64.47±6.83 pg/mL, repectively).
      IL-18 concentration of lung lavage fluid was significantly different between the positive control and steroid treatment groups
      (430.75±154.54 and 69.94±14.26pg/mL respectively, p=.028). Conclusion:In this study, IL-18 concentration increased
      not in the nasal lavage fluid but in the lung lavage fluid in AR mouse model. The increased IL-18 concentration decreased
      after the steroid therapy. This result suggests that the role of IL-18 in the pathogenesis of AR may be different from that of asthma.

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      학술지 이력

      학술지 이력
      연월일 이력구분 이력상세 등재구분
      2026 평가예정 재인증평가 신청대상 (재인증)
      2020-01-01 평가 등재학술지 유지 (재인증) KCI등재
      2017-01-01 평가 등재학술지 유지 (계속평가) KCI등재
      2013-01-01 평가 등재 1차 FAIL (등재유지) KCI등재
      2010-01-01 평가 등재학술지 선정 (등재후보2차) KCI등재
      2009-01-01 평가 등재후보 1차 PASS (등재후보1차) KCI등재후보
      2007-01-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
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      학술지 인용정보

      학술지 인용정보
      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 0.1 0.1 0.12
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0.11 0.11 0.369 0
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