목 적: 히스톤탈아세틸화효소 억제제는 그 자체의 항암효과뿐만 아니라 방사선 감작제로서의 효과가 점차 분명해져가고 있다. 최근 Class I 특이적인 히스톤탈아세틸화효소 억제제의 개발로 ...
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https://www.riss.kr/link?id=A82340087
2005
-
510
KCI등재후보,SCOPUS
학술저널
116-122(7쪽)
1
0
상세조회0
다운로드국문 초록 (Abstract)
목 적: 히스톤탈아세틸화효소 억제제는 그 자체의 항암효과뿐만 아니라 방사선 감작제로서의 효과가 점차 분명해져가고 있다. 최근 Class I 특이적인 히스톤탈아세틸화효소 억제제의 개발로 ...
목 적: 히스톤탈아세틸화효소 억제제는 그 자체의 항암효과뿐만 아니라 방사선 감작제로서의 효과가 점차 분명해져가고 있다. 최근 Class I 특이적인 히스톤탈아세틸화효소 억제제의 개발로 계층 특이적인(class specific) 연구가 가능해짐에 따라, 본 연구에서는 서로 다른 히스톤탈아세틸화효소억제제의 방사선감작효과를 비교함과 동시에 p53 발현도의 차이가 히스톤탈아세틸화효소억제제의 방사선 감수성에 미치는 영향을 알아보고자 하였다. 대상 및 방법: 이를 위해 p53 발현도가 매우 낮은 HeLa 세포에 p53의 핵 외 수송을 억제하여 세포질 내 분해를 차단하는 Leptomycin B를 처리하여 p53의 발현도를 현저하게 높인 후, Trichostatin와 SK7041의 방사선 민감도를 비교 관찰하였다. 결 과: 세포생존곡선, SER 및 SF2를 비교 분석 시, p53의 발현이 높은 Leptomycin B 처리군에서 TrichostatinA가 Class I HDAC만을 억제하는 SK7041에 비해 유의하게 높은 방사선 감작효과를 나타내었다. 이는 p53이 Class I 특이적 억제제인 SK7041과 Class I과 II를 모두 억제하는 TSA의 방사선감작효과에 미치는 영향의 차이에 기전적으로 관여함을 시사한다. 결 론: Leptomycin B에 의해 유도된 p53의 발현증가는 Class I과 Class I과 II를 모두 억제하는 TSA의 방사선 감작효과를 증강시킨다.
다국어 초록 (Multilingual Abstract)
Purpose: Histone deacetylase inhibitors (HDIs) are emerging as potentially useful components of anticancer therapy and their radiosensitizing effects have become evident. Specific HDIs are now available that preferentially inhibit specific HDAC classe...
Purpose: Histone deacetylase inhibitors (HDIs) are emerging as potentially useful components of anticancer therapy and their radiosensitizing effects have become evident. Specific HDIs are now available that preferentially inhibit specific HDAC classes; TSA inhibits Class I and II HDACs, and SK7041 inhibits Class I HDACs. Materials and Methods: We tested the differential radiosensitization induced by two different classes of HDIs in HeLa cells. We next tested the hypothesis that p53 expression in cancer cells may influence the susceptibility to HDIs by using pharmacologic modification of the p53 status under an isogenic background. Results: It is interesting that p53 expression in the HeLa cells clearly increased the degree of radiosensitization by TSA compared to that of the class I specific inhibitor SK7041. This suggests that p53 may, in part, be responsible for the mechanistic role for the greater radiosensitization induced by Class I & II inhibitors compared to that of the class I specific inhibitors. Thus, these studies are useful in distinguishing between events mediated solely by the Class I HDACs versus those events involving the other classes of HDACs as well. Conclusion: The anticancer efficacy of targeting Class I and II HDACs, in conjunction with radiation therapy, may be further enhanced by the restoration of p53 expression.
목차 (Table of Contents)
참고문헌 (Reference)
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2 "p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage" 19 : 1202-1209, 1999
3 "p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2" 20 : 1331-1340, 2001
4 "hSIR2SIRT1 functions as an NAD-dependent p53 deacetylase" 107 : 149-159, 2001
5 "Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells" 11 : 77-84, 2005
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1 "potentiated cytotoxic effect of inonizing radiation in human head and neck cancer cell lines" 22 : 138-144, 2004
2 "p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage" 19 : 1202-1209, 1999
3 "p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2" 20 : 1331-1340, 2001
4 "hSIR2SIRT1 functions as an NAD-dependent p53 deacetylase" 107 : 149-159, 2001
5 "Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells" 11 : 77-84, 2005
6 "Three proteins define a class of human histone deacetylase related to yeast Hda1p" 96 : 4868-4873, 1999
7 "Therapeutic exploration of the p53 pathway" 8 : 38-42, 2002
8 "The human histone deacetylase family" 262 : 75-83, 2001
9 "The emerging role of class II histone deactylase" 79 : 339-348, 2001
10 "The effect of functional inactivation of TP53 by HPV-E6 transformation on the induction of chromosome aberration by gamma rays in human tumor cells" 151 : 385-390, 1999
11 "The 53 gene as a modifier of intrinsic radiosensitivity:implication for radiotherapy" 40 : 197-223, 1996
12 "Susceptibility and radiosensitization of human glioblastoma cells to trichostatin A,a histone deacetylase inhibitor" 62 : 1348-1354, 2004
13 "Role of p53 status in chemosensitivity determination of cancer cells against histone deacetylase inhibitor sodium butyrate" 115 : 11-18, 2005
14 "Role of class I and Class II histone deacetylases in carcinoma cells using siRNA" 310 : 529-536, 2003
15 "Role of caspases and p53 in the apoptotic response triggered by histone deacetylase inhibitors trichostatin-A" 278 : 12579-12589, 2003
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17 "Regulation of p53 localization" 268 : 2779-2783, 2001
18 "Potential of adenoviral p53 gene therapy and irradiation for the treatment of malignant gliomas" 19 : 1041-1047, 2001
19 "Oncoprotein mdm2 is ubiquitin ligase E3 for tumor suppressor p53" 420 : 25-27, 1997
20 "Negative control of p53 by Sir2α promotes cell survival under stress" 107 : 137-148, 2001
21 "Multiple lysine mutations in the C-terminal domain of p53 interfere with MDM2-dependent protein degradation and ubiquitination" 20 : 9391-9398, 2000
22 "Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1" 242 : 540-547, 1998
23 "Leptomycin B inactivates CRM1/expotin 1 by covalent modification at a cystein residue in the central conserved region" 96 : 9112-9117, 1999
24 "Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of death receptor pathway" 11 : 71-76, 2005
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29 "Histone deacetylase inhibitors in programmed cell death and cancer therapy" 25 : 552-563, 2005
30 "Histone deacetylase inhibitors differentially stabilize acetylated p53 and induce cell cycle arrest or apoptosis in prostate cancer cells" 2005
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38 "Deacetylation of p53 modulates its effect on cell growth and apoptosis" 408 : 377-381, 2000
39 "Cytoplasmic sequestration of HDAC7 from mitochondrial and nuclear compartments upon initiation of apoptosis" 279 : 51218-51225, 2004
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비인강암의 방사선치료 결과 및 생존율에 관한 예후인자 분석
흉선상피종의 치료 성적: 예후 인자 및 방사선치료 방법에 대한 연구
학술지 이력
연월일 | 이력구분 | 이력상세 | 등재구분 |
---|---|---|---|
2024 | 평가예정 | 해외DB학술지평가 신청대상 (해외등재 학술지 평가) | |
2021-01-01 | 평가 | 등재학술지 선정 (해외등재 학술지 평가) | |
2020-12-01 | 평가 | 등재후보로 하락 (해외등재 학술지 평가) | |
2015-01-01 | 평가 | SCOPUS 등재 (기타) | |
2013-01-01 | 평가 | 등재후보 1차 FAIL (등재후보1차) | |
2012-04-01 | 평가 | 등재후보로 하락 (기타) | |
2012-01-01 | 평가 | 등재후보학술지 유지 (기타) | |
2011-12-30 | 학회명변경 | 영문명 : The Korean Society For Therapeutic Radiology And Oncology -> The Korean Society for Radiation Oncology | |
2011-08-22 | 학술지명변경 | 한글명 : 대한방사선종양학회지 -> Radiation oncology journal 외국어명 : The Journal of the Korean Society for Therapeutic Radiology and Oncology -> Radiation oncology journal | |
2009-01-01 | 평가 | 등재 1차 FAIL (등재유지) | |
2006-01-01 | 평가 | 등재학술지 선정 (등재후보2차) | |
2005-01-01 | 평가 | 등재후보 1차 PASS (등재후보1차) | |
2004-01-01 | 평가 | 등재후보학술지 유지 (등재후보1차) | |
2002-01-01 | 평가 | 등재후보학술지 선정 (신규평가) |
학술지 인용정보
기준연도 | WOS-KCI 통합IF(2년) | KCIF(2년) | KCIF(3년) |
---|---|---|---|
2016 | 0.31 | 0.31 | 0.25 |
KCIF(4년) | KCIF(5년) | 중심성지수(3년) | 즉시성지수 |
0.23 | 0.22 | 0.864 | 0.05 |