腦下垂體 腺腫의 各種 호르몬 生成에 關한 免疫組織化學的 硏究 = An Immunohistochemical study on localization of Growth hormone, Prolactin and ACTH in pituitary adenoma.

다국어 초록 (Multilingual Abstract)

Before introduction of immunoperoxidase technic, routine histologic examination of the pituitary tumor without information on clinical and laboratory findings was rarely possible to predict functional activity of the tumor. The author had performed an immunoenzyme histochemistry on 18 cases of formalin fixed and paraffin embedded surgical specimens of pituitary adenomas using antihuman antibodies of growth hormone(GH), prolactin(PRL), and adrenocorticotrophic hormone(ACTH). And the findings obtained from microscopic examination were compared with the results of hormonal assay of the serum in each case.
The results obtained are as follows;
1. By radioimmunoassay, 18 cases of pituitary adenoma corresponded with PRL producing adenomas in 7 cases, GH producing adenomas in 3 cases, ACTH producing adenoma in 1 case, GH and PRL producing adenomas in 4 cases, GH and ACTH producing adenoma in 1 case and noiisecretory 2 cases.
2. Immunoperoxidase staining of 18 cases of pituitary adenomas revealed GH producing adenomas in 3 cases, PRL producing adenomas in 3 cases, ACTH producing adenoma in 1 case, GH and PRL producing adenomas in 6 cases, PRL and ACTH producing adenoma in 1 case, GH, PRL, and ACTH producing adenoma in 1 case, and nonsecretory (as far as GH, PRL, and ACTH are concerned) adenoma in 3 cases.
3. correiation between findings of tissue and serum in individual case revealed complete matching in 7 cases (38.9%), partial matching in 9 cases(50.0%), and non-matching in 2 casrs(11.1%).
Considering above results, the author proposes to classify pituitary adenomas in combination of tissue and serum findings.