Apoptosis에서의 Fas 항원의 역할 : (정상 각질형성 세포의 apoptosis에 대한 Fas 항원의 역할) = The Role of Fas Antigen in Apoptosis

다국어 초록 (Multilingual Abstract)

Fas s a cell surface receptor molecule belonging to the tumor-necrosis factor receptor/nerve growth factor receptor family expressed in a number of cell types including normal human keratinocytes. After Fas ligand, a cell surface molecule belonging to the tumor necrosis factor family, is attached to Fas, apoptosis is induced via several signal transduction pathways In the fate of T lymphocytes, Fas is involved in peripheral clonal deletion, activation-induced cell death, and, in some situation, proliferation and activation Mutation of Fas antigen causes autommune lymphoproliferative syndrome in human. Soluble Fas maed by different splicing of Fas mRNA may be related to the pathogenesis of systemic lupus erythematosus. On the contrary, the overactivity of th Fas system may cause tissue destructions shown in AIDS and acute fulminant hepatitis.
In skin, the Fas antigen may cause apoptosis occurring in inflammatory skin diseases, but its role in terminal differentiation of normal keratinocytes is not clear at present.



























































There are many conditions characterized by nests of cells within the epidermis One of them, hidroacanthoma simplex, has been regarded as an epidermal tumor differentiating to intraepidermal eccrine duct cell. We report a case of hidroacanthoma simplex with the results of immunohistochemical study. Staining for 35βH11(reacting with keratin No.8), 35βE12(reacting with keratin No1, 5, 10, 11), S-100 protein, and CEA was negative in the tumor cell nests; these monoclonal antibodies stained the nests of eccrine poroma.

목차 (Table of Contents)

• 정상 각질형성 세포의 apoptosis에 대한 Fas 항원의 역할
• Fas/APO-1/CD95항원의 발견
• Fae 항원의 구조
• Fas 리간드(FasL)
• Fas 항원의 신호전달 체계
• lpr 과 gld 변이를 보이는 생쥐
• Fas수용체의 작용
• Fas 항원이 관련된 질환
• 피부에서의 Fas 항원의 역할
• 참고문헌
• A Case of Hidroacanthoma Simplex
• Abstract
• Introduction
• Case Report
• Discussion
• References