한국인에서 5-HT_(1Dβ) 유전자다형성과 성격 특성 = Polymorphisms in 5-HT_(1Dβ) Receptor Gene and Personality Traits in a Korean Population

다국어 초록 (Multilingual Abstract)

Objectives : Recently, there has been a growing enthusiasm in biological approach to personality ; the identification of genes responsible for particular personality traits. The aim of this study was to investigate the association between the 5-HT_(1Dβ) G861C polymorphism and personality traits.
Methods : We recruited 218 normal subjects. The Korean version of the Temperament and Character Inventory (TCI) was used to assess personality traits. From blood samples taken from the subjects, DNA was isolated using standard techniques and the HT_(1Dβ) G861C polymorphism was genotyped by means of polymerase chain reaction and Homogeneous MassEXTEND method. We classified the subject into the GG, CG, and GG groups according to their genotypes. The differences in the temperament factors of the TCI between homozygote group (GG+CC genotype) and heterozygote group (CG genotype) weretested.
Results : The heterozygote group had significantly lower Harm avoidance (HA) scores and higher Self-directedness scores(SD) than the homozygote group.
Conclusion : In conclusion, we found some associations between the 5-HT_(1Dβ) G861C polymorphism and the personality dimension HA and SD in a normal population.

참고문헌 (Reference)

1 "serotonin transporter promoter gene polymorphicregion(5-HTTLPR)and personality in female patients with seasonalaffective disorder and in healthy controls" 14 : 53-58, 2004

2 "receptorfunction and personality traits in healthy subjects: a negativestudy" 68 : 235-241, 2002

3 "The serotonin 5-HT1B receptor gene and attention deficit hyperactivitydisorder" 8 : 98-102, 2003

4 "The neurobiology and pharmacology of depression:acomparative review of serotonin selective andtidepressants" 87 : 540-552, 1997

5 "The HTR1B 861G>C receptor polymorphism among patientssuffering from alcoholism,major depression,anxiety disorders andnarcolepsy" 97 : 1-10, 2000

6 "Sumatriptan challengein bipolar patients with and without migraine:a neuroendocrinestudy of 5-HT1D receptor function" 17 : 33-36, 2002

7 "Substance abuse disorder and major depression areassociated with the human 5-HT1B receptor gene(HTR1B)G861Cpolymorphism" 28 : 163-169, 2003

8 "Standization study of Korean version Beck Depression Inventory" 25 : 487-500, 1986

9 "Serotonergic genesand personality traits in the Korean population" 354 : 2-5, 2004

10 "Role of serotonintransporter gene in temperament and character" 13 : 312-328, 1999

11 "Reliability andvalidity of the Korean version of the temperament and character inventory" 43 : 235-243, 2002

12 "Relationship ofpsychopathology to the human serotonin 1B genotype and receptorbinding kinetics in post-mortem brain tissue" 21 : 238-246, 1999

13 "Relationship between serotonin and the Temperament and CharacterInventory" 89 : 29-37, 1998

14 "Prefrontal 5-HT2a receptor binding index,hopelessnessand personality characteristics in attempted suicide" 74 : 149-158, 2003

15 "Polymorphism of the serotonin 5-HT1B receptor gene(HTR1B)associated with minimum lifetime body mass index inwomen with bulimia nervosa" 50 : 640-643, 2001

16 "Platelet serotonin,monoamine oxidase activity,and[3H]paroxetine binding related to impulsive suicide attempts andborderline personality disorder" 43 : 740-746, 1998

17 "No evidence of an association between 5HT1B receptor genepolymorphism and suicide victims in a Japanese population" 105 : 343-345, 2001

18 "No association between the serotonin transporter gene regulatoryregion polymorphism and the Tridimensional Personality Questionnaire(TPQ)temperament of harm avoidance" 2 : 224-226, 1997

19 "Lowering of serotonin by rapid tryptophan depletion increaseimpulsiveness in normal individuals" 164 : 385-391, 2002

20 "Linkage of antisocial alcoholism to the serotonin 5-HT1B receptorgene in 2 populations" 55 : 989-994, 1998

21 "Genes,environment,and personality" 264 : 1700-1701, 1994

22 "Clinical study of Korean version Beck AnxietyInventory:comparisons between patients and non-patients groups" 16 : 185-197, 1997

23 "Association of anxiety-related traits with a polymorphism in the serotonintransporter gene regulatory region" 274 : 1527-1531, 1996

24 "Allelic variation in 5-HT1A receptor expression is associated withanxiety- and depression-related personality traits" 110 : 1445-1453, 2003

25 "A systematic method for clinical description and classificationof personality variants" 44 : 573-588, 1987

26 "A psychobiological modelof temperament and character" 50 : 975-990, 1993

27 "A polymorphism in the serotonin receptor 3A(HTR3A)geneand its association with harm avoidance in women" 60 : 1017-1023, 2003

28 "A human serotonin 1D receptor variant(5HT1Dbeta)encoded by an intronless gene on chromosome 6" 89 : 5522-5526, 1992

29 "5HT1Dbeta Receptor gene implicated in the pathogenesis of Obsessive-Compulsive Disorder:further evidence from a family-basedassociation study" 7 : 805-809, 2002

30 "5-HT2a receptor polymorphism gene in bipolar disorderand harm avoidance personality trait" 96 : 360-364, 2000