Diazepam이 기억과 정신운동수행에 미치는 효과에 대한 연구 = Effects of Diazepam on Memory and Psychomotor Performance

다국어 초록 (Multilingual Abstract)

The author studied the effects of diazepam on memory and psychomotor performance in 19 healthy male student volunteer. The subjects were divided into two groups; the experimental group of ten subjects and the control group of nine subjects. Fifteen ㎎ of diazepam was administered orally to the experimental subjects and each 5cc of venous blood was sampled consecutively at 15 minutes, 30 minutes, 90 minutes and 120 minutes after drug administration. The serum level was measured by enzyme multiplied immunological technique (EMIT). For the control group, placebo was given orally. Memory function and psychomotor performance of both the experimental and control groups were tested just before, at 15 minutes, 30 minutes, 90 minutes and 120 minutes after drug administration. The tools used for evaluation of memory function and psychomotor performance were memory cards which were word stimuli prepared by the author and digit-symbol substitution of Korean Wechsler Intelligence Scale.
The results of the study were as follows :
1. In the experimental group, mean serum level were 0.1±0.4㎍/㎖ at 15 minutes, 0.14±0.08㎍/㎖ at 30 minutes, 0.36±0.19㎍/㎖ at 90 minutes and 0.37±0.14㎍/㎖ at 120 minutes after oral administration of diazepam 15㎎.
2. In the control group, no significant chronological change was statistically noticed in the memory function and psychomotor performance.
3. The degree of memory impairment was increased as time passed until 120 minutes in the experimental group. Memory function showed reversed correlation to the serum diazepam level (r=-0.5116). Memory impairment was more prominent in the subjects with higher serum level.
4. The impairment of psychomotor performance was increased as time passed until 120minutes in the experimental group. Serum diazepam level and psychomotor performance showed reversed correlation (r=-0.5070). The psychomotor performance was impaired more profoundly in the subjects with higher serum level.