Adult mongrel dog of either sex weighing 10-14㎏ were anesthetized with pentobarbital sodium, and hydrated with 0.9% saline solution, and then furosemide or ethacrynic acid was nfused through the left renal artery withi various dose, and right and le...
Adult mongrel dog of either sex weighing 10-14㎏ were anesthetized with pentobarbital sodium, and hydrated with 0.9% saline solution, and then furosemide or ethacrynic acid was nfused through the left renal artery withi various dose, and right and left side of urine were collected through the polyethylene tubes inserted in both ureters.
The change of urine volume was as follows.
1. Furosemide : with 0.5㎍/㎏/min. the urinary volume of the both kidney was not increased, but with 1㎍, 2㎍, and 5㎍/㎏/min, the urinary volume of the left kidney was increased significantly. with 10㎍/㎏/min, the urinary volume of the both kidney was increased markedly, especially in the left kidey.
2. Ethacrynic acid: with 1㎍/㎏/mjn, the urinary volume of the both kidney was not increased so markedly, but 2㎍/5㎍/min, it was increased significantly in the left kidney. with 10㎍/㎏/min, The urinary volume of the both kidney was increased markedly, especially in the left kidney.