유육종증 = Sarcoidosis

다국어 초록 (Multilingual Abstract)

Sarcoidosis is a systemic granulomatous disease of unknown etiology that mainly develops

between 25 and 40 years of age and primarily affects the lungs and the lymphatic system.

Generally accepted pathogenic hypothesis is that certain environmental agents could promote

sarcoidosis in genetically susceptible hosts. The characteristic lesion of sarcoidosis is a

noncaseating granuloma that consist of epithelioid cells and T lymphocytes. Diverse clinical

courses are observed according to the epidemiologic factors, involved organs, and disease

severity. Spontaneous remissions occur in approximately two thirds of patients, but the course is

chronic or deteriorative in 10 to 30%. Mortality, ranging between 1 and 5%, is mostly related to

progressive respiratory insufficiency, or central nervous system or myocardial involvement. The

mainstay of treatment for sarcoidosis is systemic corticosteroid administration. However, the

indication, optimal dose, and duration of corticosteroid therapy continue to be controversial.

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