CAPD 중인 환자에서 Captopril 투여 후 발생한 범혈구감소증 1 예 = A Case of Captopril - Induced Pancytopenia in Patient Undergoing CAPD

다국어 초록 (Multilingual Abstract)

Captopril, an angiotensin converting enzyme inhibitors, has been used increasingly for the treatment of hypertension and glomerulonephritis with proteinuria. Not only are they efficacious but the incidence of serious adverse effect with ACE inhibitors is similar to that with placebo. Hut they have been rarely associated with serious adverse effect such as agranulocytosis or pancytopenia. A 58-year-old man undergoing peritoneal dialysis for end stage renal disease secondary to chronic essential hypertension was admitted because of sore throat and abdominal pain. The patient has taken captopril, nifedipine and furosemide for fifteen months. Seven days before he was admitted, sore throat, skin rash on the right lower leg were noted. On admission, CBC revealed pancytopenia. The captopril was discontinued and all other medications remained same. Pancytopenia and skin rash improved completely in eight hospital days. We report a case of severe captopril-induced pancytopenia with a review of literature.