단순포진각막염 환자에서 발생한 진균각막염 3예 = Three Cases of Secondary Fungal Infection in Herpes Simplex Keratitis

다국어 초록 (Multilingual Abstract)

Purpose: To report several cases of secondary infection by fungus in herpes simplex keratitis. Case summary: A retrospective chart review was performed on 3 eyes of 3 patients who were without improvement and diagnosed with fungal keratitis by smear and culture on prior presentation with herpetic keratitis. Two cases were diagnosed with fungal keratitis, based on the results of culture. Fungal keratitis by Candida albicans was improved with antifungal agents, but a case caused by Fusarium species was more aggravated, regardless of antifungal agents. One case was improved by antifungal medications, which was diagnosed with fungal keratitis by the fungal hyphae manifestation on KOH preparation. Conclusions: Secondary microbial infection should be considered, when the lesion had no improvement with antiviral agents in herpetic keratitis. J Korean Ophthalmol Soc 2010;51(9):1271-1275

참고문헌 (Reference)

1 이광훈, "진균각막염에서 치료실패의 위험인자에 대한 분석" 대한안과학회 49 (49): 737-742, 2008

2 김경훈, "보리코나졸로 치료한 진균안감염" 대한안과학회 49 (49): 1054-1060, 2008

3 Boisjoly HM, "Superinfections in herpes simplex keratitis" 96 : 354-361, 1983

4 Malecha MA, "Successful treatment of Paecilomyces lilacinus keratitis in a patient with a history of herpes simplex virus keratitis" 25 : 1240-1242, 2006

5 Nissenkorn I, "Secondary bacterial infections in herpes simplex keratitis" 14 : 757-759, 1982

6 Wong TY, "Risk factors and clinical outcomes between fungal and bacterial keratitis: a comparative study" 23 : 275-281, 1997

7 Gopinathan U, "Review of epidemiological features, microbiological diagnosis and treatment outcome of microbial keratitis: experience of over a decade" 57 : 273-279, 2009

8 O'Connor GR, "Recurrent herpes simplex uveitis in humans" 21 : 165-170, 1976

9 Matoba AY, "Polymicrobial keratitis secondary to Burkholderia ambifaria, Enterococcus, and Staphylococcus aureus in a patient with herpetic stromal keratitis" 136 : 748-749, 2003

10 Butler TK, "Infective keratitis in older patients: a 4 year review, 1998-2002" 89 : 591-596, 2005

11 Thomas PA, "Infectious keratitis" 20 : 129-141, 2007

12 Kaye S, "Herpes simplex keratitis" 25 : 355-380, 2006

13 Binder PS, "Herpes simplex keratitis" 21 : 313-331, 1977

14 Del Prete A, "Fungal keratitis due to Scopulariopsis brevicaulis in an eye previously suffering from herpetic keratitis" 208 : 333-335, 1994

15 Van der Meulen IJ, "Age-related risk factors, culture outcomes, and prognosis in patients admitted with infectious keratitis to two Dutch tertiary referral centers" 27 : 539-544, 2008

16 Rodriguez-Ares T, "Acremonium keratitis in a patient with herpetic neurotrophic corneal disease" 78 : 107-109, 2000