본 연구에서는 흑마늘 열수 추출물(ABG)의 암세포 전이억제 효능을 검정하였다. AGS AGS 인체위암세포의 이동성과 침윤성을 억제하였으며, 이는 TER의 증가와 연관성이 있었다. 또한 ABG에 의한 A...
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https://www.riss.kr/link?id=A82319685
2010
Korean
KCI등재
학술저널
528-534(7쪽)
6
0
상세조회0
다운로드국문 초록 (Abstract)
본 연구에서는 흑마늘 열수 추출물(ABG)의 암세포 전이억제 효능을 검정하였다. AGS AGS 인체위암세포의 이동성과 침윤성을 억제하였으며, 이는 TER의 증가와 연관성이 있었다. 또한 ABG에 의한 A...
본 연구에서는 흑마늘 열수 추출물(ABG)의 암세포 전이억제 효능을 검정하였다. AGS AGS 인체위암세포의 이동성과 침윤성을 억제하였으며, 이는 TER의 증가와 연관성이 있었다. 또한 ABG에 의한 AGS 위암세포의 침윤성 억제는 TIMPs 발현 증가에 의한 MMPs의 발현 및 활성 저하에 의한 것임을 알 수 있었다. 아울러 AGS 위암세포에서 과발현을 나타내는 TJ 단백질인 claudins의 발현 저하 등이 ABG의 항전이 효과에 연관되어 있음을 알 수 있었다. 이상의 결과는 흑마늘 열수 추출물이 단순한 암세포의 증식억제를 통한 암예방 및 항암활성 뿐만 아니라 암세포의 전이 또한 효과적으로 억제할 수 있음을 보여주며, 이와 연관된 보다 구체적인 분자세포생물학적 접근 및 in vivo 연구의 필요성이 요구됨을 의미한다.
다국어 초록 (Multilingual Abstract)
Garlic (Allium sativum) has been well-known as a folk remedy for a variety of ailments since ancient times, and it is well documented that enhanced garlic consumption leads to a decrease in incidences of cancer. Tight junctions (TJs) are critical stru...
Garlic (Allium sativum) has been well-known as a folk remedy for a variety of ailments since ancient times, and it is well documented that enhanced garlic consumption leads to a decrease in incidences of cancer. Tight junctions (TJs) are critical structures for the maintenance of cellular polarity, acting as paracellular permeability barriers and playing an essential role in regulating the diffusion of fluid, electrolytes and macromolecules through the paracellular pathway. Matrix metalloproteinases (MMPs) have been implicated as possible mediators of invasiveness and metastasis in some cancers. In this study, we investigated the potential effects of water extract of aged black garlic (ABG) on the correlation between tightening of TJs and anti-invasive activity in human gastric carcinoma AGS cells. The inhibitory effects of ABG on cell motility and invasiveness were found to be associated with increased tightness of TJs, which was demonstrated by an increase in transepithelial electrical resistance. Additionally, the activities of MMP-2 and -9 in AGS cells were inhibited by treatment with ABG, and this was also correlated with a decrease in the expression of their mRNA and proteins. Furthermore, RT-PCR and immunoblotting results indicated that ABG repressed the levels of the claudin proteins, major components of TJs that playa key role in the control and selectivity of paracellular transport. In conclusion, these results suggest that ABG treatment may inhibit tumor metastasis and invasion, and therefore may act as a dietary source to decrease the risk of developing cancer.
목차 (Table of Contents)
참고문헌 (Reference)
1 박 철, "흑마늘 추출물의 NF-κB 비활성화를 통한 Cyclooxygenase-2 발현 및 Prostaglandin E2의 생성 억제" 대한암예방학회 14 (14): 161-170, 2009
2 신동역, "흑마늘 추출물에 의한 AGS 인체 위암세포의 Apoptosis 유도에 관한 연구" 대한암예방학회 14 (14): 350-358, 2009
3 Martinez, P. A., "Ultrastructural modifications of intercellular junctions between tumor cells" 22 : 605-614, 1970
4 Peralta, S. A., "Tissue remodeling during tumor necrosis factor-induced apoptosis in LLC-PK1 renal epithelial cells" 270 : F869-F879, 1996
5 Schneeberger, E. E., "The tight junc-tion: a multifunctional complex" 286 : C1213-C1228, 2004
6 Tak, P. P., "The pathogenesis and prevention of joint damage in rheumatoid arthritis: advances from synovial biopsy and tissue analysis" 43 : 2619-2633, 2000
7 Madara, J. L., "The movement of solutes and cells across tight junctions" 664 : 47-60, 1992
8 Van Itallie, C. M., "The molecular physiology of tight junction pores" 19 : 331-338, 2004
9 Yokoyama, K., "Reverse correlation of E-cadherin and snail expression in oral squamous cell carcinoma cells in vitro" 37 : 65-71, 2001
10 McCartney, M. D., "Rabbit corneal epithelial wound repair: tight junction reformation" 11 : 15-24, 1992
1 박 철, "흑마늘 추출물의 NF-κB 비활성화를 통한 Cyclooxygenase-2 발현 및 Prostaglandin E2의 생성 억제" 대한암예방학회 14 (14): 161-170, 2009
2 신동역, "흑마늘 추출물에 의한 AGS 인체 위암세포의 Apoptosis 유도에 관한 연구" 대한암예방학회 14 (14): 350-358, 2009
3 Martinez, P. A., "Ultrastructural modifications of intercellular junctions between tumor cells" 22 : 605-614, 1970
4 Peralta, S. A., "Tissue remodeling during tumor necrosis factor-induced apoptosis in LLC-PK1 renal epithelial cells" 270 : F869-F879, 1996
5 Schneeberger, E. E., "The tight junc-tion: a multifunctional complex" 286 : C1213-C1228, 2004
6 Tak, P. P., "The pathogenesis and prevention of joint damage in rheumatoid arthritis: advances from synovial biopsy and tissue analysis" 43 : 2619-2633, 2000
7 Madara, J. L., "The movement of solutes and cells across tight junctions" 664 : 47-60, 1992
8 Van Itallie, C. M., "The molecular physiology of tight junction pores" 19 : 331-338, 2004
9 Yokoyama, K., "Reverse correlation of E-cadherin and snail expression in oral squamous cell carcinoma cells in vitro" 37 : 65-71, 2001
10 McCartney, M. D., "Rabbit corneal epithelial wound repair: tight junction reformation" 11 : 15-24, 1992
11 Mullin, J. M., "Potential interplay between luminal growth factors and increased tight junction permeability in epithelial carcinogenesis" 279 : 484-489, 1997
12 Riehl, T. E., "Mechanisms of transit of lipid mediators of inflammation and bacterial peptides across intestinal epithelia" 267 : G687-G695, 1994
13 Birkedal-Hansen, H., "Matrix metalloproteinases: a review" 4 : 197-250, 1993
14 Chandler, S., "Matrix metalloproteinases, tumor necrosis factor and multiple sclerosis: an overview" 72 : 155-161, 1997
15 Consolo, M., "Matrix metalloproteinases and their inhibitors as markers of inflammation and fibrosis in chronic liver disease" 24 : 143-152, 2009
16 Swift, J. G., "Intercellular junctions in hepatocellular carcinoma" 15 : 799-810, 1983
17 Rawlings, N. D., "Evolutionary families of metallopeptidases" 248 : 183-228, 1995
18 Katoh, M., "Epithelial-mesenchymal transition in gastric cancer" 27 : 1677-1683, 2005
19 Chauhan, N. B., "Effect of aged garlic extract on APP processing and tau phosphorylation in Alzheimer's transgenic model Tg2576" 108 : 385-394, 2006
20 Tunggal, J. A., "E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions" 24 : 1146-1156, 2005
21 Morita, K., "Claudin multigene family encoding fourtransmembrane domain protein components of tight junction strands" 511-516, 1996
22 Ariga, T., "Antithrombotic and anticancer effects of garlic-derived sulfur compounds: a review" 26 : 93-103, 2006
23 Khanum, F., "Anticarcinogenic properties of garlic:a review.Crit.Rev.Food Sci.Nutr.44,479-488" 44 : 479-488, 2004
24 Allison, G. L., "Aged garlic extract and its constituents inhibit platelet aggregation through multiple mechanisms" 136 : 782S-788S, 2006
25 Ahmad, M. S., "Aged garlic extract and S-allyl cysteine prevent formation of advanced glycation endproducts" 561 : 32-38, 2007
26 Wong, A. S., "Adhesion-independent mechanism for suppression of tumor cell invasion by E-cadherin" 161 : 1191-1203, 2003
Differential Expression Patterns of Gangliosides in the Liver and Heart of NIH-miniature Pigs
운동강도의 차이가 60주령된 흰쥐의 Soleus와 EDL에서 Bcl-2, Bax, caspase-3와 DNA 절편화에 미치는 영향
Mycobacteria에 대해 항균력을 나타내는 엉겅퀴의 분류를 위한 ITS1, 5,8S rRNA, ITS2의 염기서열 분석
학술지 이력
연월일 | 이력구분 | 이력상세 | 등재구분 |
---|---|---|---|
2027 | 평가예정 | 재인증평가 신청대상 (재인증) | |
2021-01-01 | 평가 | 등재학술지 유지 (재인증) | |
2018-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2015-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2011-08-03 | 학술지명변경 | 외국어명 : Korean Journal of Life Science -> Journal of Life Science | |
2011-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2009-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2007-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2004-01-01 | 평가 | 등재학술지 선정 (등재후보2차) | |
2003-01-01 | 평가 | 등재후보 1차 PASS (등재후보1차) | |
2001-07-01 | 평가 | 등재후보학술지 선정 (신규평가) |
학술지 인용정보
기준연도 | WOS-KCI 통합IF(2년) | KCIF(2년) | KCIF(3년) |
---|---|---|---|
2016 | 0.37 | 0.37 | 0.42 |
KCIF(4년) | KCIF(5년) | 중심성지수(3년) | 즉시성지수 |
0.43 | 0.43 | 0.774 | 0.09 |