AIDS vaccine research and clinical trials

목차 (Table of Contents)

• CONTENTS
• Foreword / Salvador E. Luria = ⅲ
• Preface = vii
• Contributors = xv
• Properties of HIV Relevant to Vaccine Development = 1
• 1. Features of the HIV Envelope and Development of a Subunit Vaccine / Scott D. Putney ; Kashi lavaherian ; James Rusche ; Thomas Matthews ; Dani P. Bolognesi = 3
• 2. Interaction of HIV with Its Cellular Receptor, CD4 : Prospects for Immunologic Intervention / Gregg M ; Orloff ; J. Steven McDougal = 63
• 3. Structure and Function of the HIV Envelope : Implications for Vaccine Development / Joseph Sodroski ; Mark Kowalski ; William Haseltine = 93
• 4. Conserved and Divergent Features of Human and Simian Immunodeficiency Viruses / Genoveffa Franchini ; Flossie Wong-Staal = 107
• 5. Genetic Variability in Human Immunodeficiency Viruses / Beatrice H Hahn ; George M. Shaw = 121
• Cellular Immune Response Relevant to Vaccine Development
• 6. T-Cell Immunity and Vaccine Engineering : Application to the AIDS Virus / Kemp B. Cease ; Jay A. Berzofsky = 139
• 7. Anti-HW-1 ADCC / H. Kim Lyerly ; Douglas S. Tyler ; Chet L. Nastala ; Kent J. Weinhold = 157
• 8. Cytotoxic T-Lymphocyte Responses to HIV-1 in Infected Individuals / Bruce D. Walker = 179
• Development of Vaccine Candidates
• 9. Biochemical and Immunologic Characterizations of HIV Envelope Glycoproteins Expressed by Recombinant Vaccinia Virus / Shiu-Lok Hu = 197
• 10. Large-Scale Production, Purification, and Immunologic Analysis of a Vaccinia Recombinant Derived HIV-1 gp160 / Friedrich Dorner ; Noel Barrett ; Benard Moss = 219
• 11. CD4-gp120 Interaction : Idiotype Mimicry as Putative Vaccines and Therapeutics Against HIV Infection / Ronald C. Kennedy ; Vernon C. Maino ; Noel L. Warner ; Tran C. Chanh, ; Wayne C. Koff = 241
• 12. Prophylactic and Therapeutic Immunization Against AIDS : Theoretical Considerations Underlying a Modified Noninfectious Whole Virus Approach / Jonas Salk with Merril S. Gersten = 265
• Animal Models for Vaccine Development and Efficacy Studies
• 13. Equine Infectious Anemia Vims : A Natural Model for the Immunologic Management of Lentivirus Infections / Ronald C. Montelaro ; Charles J Issel ; Susan L. Payne, ; Keith Rushlow = 279
• 14. Induction of Protective Immunity Against an Immunosuppressive Mouse Retrovirus : Possible Parallels with HIV / Bruce Chesebro = 301
• 15. Epitomes Responsible for Fusion and Virus Neutralization in the Glycoprotein of Ovine and Caprine Lentiviruses : A Challenge for Vaccine Development / Susan L. Gdovin ; Sharon E. Crane ; Opendra Narayan ; Janice E. Clements = 319
• 16. Infection of Nonhuman Primates with Human and Simian Immuno deficiency Viruses / Patricia N. Fultz ; Harold M. McClure ; Daniel C. Anderson = 339
• 17. Relevant Aspects of HIV-Related Viruses to Vaccine Development / Phyllis J. Kanki ; Jorg W. Eichberg ; Max Essex = 351
• 18. Un of Simian Immunodeficiency Virus for AIDS Vaccine Research / Ronald C. Desrosiers ; Yen Li, ; Muthiah D. Daniel = 361
• 19. A Specific Antibody Activity that Neutralizes HIV Infectivity In Vivo / Emilio A. Emini = 369
• Clinical Trials and Regulatory Considerations
• 20. Recombinant-Derived Hepatitis B Vaccine : A Paradigm for Other Subunit Vaccines / Ronald W. Ellis = 381
• 21. HIV-1 Infection in Central Africa : Some Epidemiologic and Prevention Aspects / Grard Agius ; Isabelle Desportes ; Gigliola Flamminio-Zola ; Z. Lurhuma ; J. J. Salaun ; Robert C. Gallo ; Daniel Zagury = 409
• 22. Clinical Trials of AIDS Vaccines / Wayne C. Koff ; Susan L. Wescott ; Daniel F. Hoth = 425
• 23. AIDS Vaccines : Regulatory, Scientific, and Ethical Issues / Alec E. Wittek ; Gerald V. Quintan, Jr. = 439
• Recent Developments = 469
• Index = 477