越婢加朮湯의 항산화 및 항염증 효과에 대한 연구 = The Study on Anti-Oxidant and Anti-Inflammatory Effects of Wolbigachul-tang

다국어 초록 (Multilingual Abstract)

Objectives This study was conducted to find out the antioxidant and inflammatory improvement effects of Wolbigachul-tang.
Methods To evaluate the antioxidant and anti-inflammatory effects of wolbigachul- tang, the total polyphenol and flavonoid contents were measured. And radical scavenging function was measured. In addition reactive oxygen species, nitric oxide, cytokines productions were measured by treating wolbigachul-tang in the lipopolysaccharide- induced RAW264.7 cells. We also measured the gene expression of inducible nitric oxide synthase, cyclooxygenase-2, cytokines too.
Results Radical scavenging experiments showed significant concentration-dependent scavenging capacity increase. The amount of reactive oxygen species, nitric oxide, cytokines production in the cell all showed a significant concentration-dependent decrease compared to the control group. The gene expression of inducible nitric oxide synthase, cyclooxygenase-2, and cytokines also showed a significant concentration- dependent decrease compared to the control group.
Conclusions In conclusion, it is believed that wolbigachul-tang can be applied to various inflammatory diseases. (J Korean Med Rehabil 2023;33(1):1-12)