Specific Pathogen-Free BALB/c 마우스와 C57BL/6 마우스의 혈액학 및 혈액생화학 지표 = Hematological and Serum Biochemical Values in Specific Pathogen-Free BALB/c and C57BL/6 Mice

다국어 초록 (Multilingual Abstract)

Establishment of the basic data line is very important in the evaluation of the result of clinical and/or nonclinical experiments, in the improvement the confidence of test results. A reference range data base containing serum chemistry and hematology values in 5 weeks old BALB/c and C57BL/6 mice which were purchased from the different companies is described. Hematological parameters are white blood cell count, red blood cell count, hemoglobin concentration, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, platelet count. In the BALB/c mice, there are significant differences observed between lots, sexes and strains. In the C57BL/6 mice, there are significant differences observed between lots and strains but no significant differences observed between sexes. Serum biochemistry parameters are aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, blood urea nitrogen, creatinine, glucose, total cholesterol, total bilirubin, total protein, albumin, triglyceride, calcium, inorganic phosphate, phospholipid, high density lipoprotein cholesterol, low density lipoprotein cholesterol, albumin globulin ratio, sodium, potassium, chloride. In both stains of mice, there are significant differences observed between lots, sexes and strains. Data from the present study will support in the proper interpretation and validation of these results.

목차 (Table of Contents)

• 재료 및 방법
• 결과
• 고찰
• 참고문헌