고농도 Dopamine 희석액의 안정성 = Stability of High-concentration Dopamine Hydrochloride in 5% Dextrose

다국어 초록 (Multilingual Abstract)

Dopamine, the precursor of norepinephrine, is used in acute heart failure, cardiogenic shock, and oliguria. Dopamine is administered as the hydrochloride by intravenous infusion diluted in 5% dextrose, 0.9% sodium chloride, or other suitable diluents. Usually dopamine HCI is available for infusion in concentration of 0.8, 1.6, and 3.2 ㎎/㎖ in dextrose 5%. But, in the ICU, the more concentrated 4, 8, rarely 16 ㎎/㎖ solutions may be preferred in patients who are to be fluid-restricted or to whom a slower rate of infusion is desired. Therefore we studied the stability of high-concentration dopamine HCI in 5% dextrose at ambient temperature through evaluating the contents of dopamine by HPLC method and confirmed pH and osmotic values. The results showed that the t_(90)(C_(t)>90% C_(O)) of dopamine HCl solutions was 33.63, 29.75, and 25.79 hrs for the 4, 8, and 16 ㎎/㎖ concentrations, respectively. In conclusion, each solution was stable for at least 24 hrs. Small decrease in pH was observed for the 48-hour study period. But, during that times the osmolarity in each concentration was not significantly different.