Colliodal mesoporous silica nanoparticles as strong adhesives for hydrogels and biological tissues

다국어 초록 (Multilingual Abstract)

Colloidal mesoporous silica (CMS) nanoparticles are evaluated as an adhesive for hydrogels or biological tissues. Because the adhesion energy is proportional to the surface area of the nanoparticles, the CMS nanoparticles could provide a stronger adhesion between two hydrogels than the nonporous silica nanoparticles. In the case of 50 nm CMS nanoparticles with a pore diameter of 6.45 nm, the maximum adhesion energy was approximately 35.0 J/m2 at 3.0 wt %, whereas the 10 wt % nonporous silica nanoparticle solution showed only 7.0 J/m2. Moreover, the CMS nanoparticle solution had an adhesion energy of 22.0 J/m2 at 0.3 wt %, which was 11 times higher than that of the nonporous nanoparticles at the same concentration. We also found optimal pore diameter from maximum adhesion energy of various CMS nanoparticles. Moreover, these CMS nanoparticles are demonstrated for adhering incised skin tissues of mouse, resulting in rapid healing even at a lower nanoparticle concentration. Finally, the CMS nanoparticles had added benefit of quick degradation in biological media because of their porous structure, which may prevent unwanted accumulation in tissues.

목차 (Table of Contents)

• Abstract 1
• 1. Introduction 2
• 2. Experimental Section 7
• 2.1 Synthesis of colloidal mesoporous silica (CMS) nanoparticles 7
• 2.2 Adsorption measurement 10
• 2.3 Preparation of PDMA hydrogels and adhesion test 10
• 2.4 In vitro cytotoxicity test and in vivo mouse study 13
• 2.5 Degradation study of CMS nanoparticles 14
• 2.6 Characterizations 14
• 3. Result and Discussions 16
• 3.1 Synthesis and characterizations of CMS nanoparticles 16
• 3.2 Adsorption measurement and adhesion test 22
• 3.3 Optimal total outer surface area 31
• 3.4 Optimal pore diameter 38
• 3.5 In vitro cytotoxicity test and in vivo mouse study 44
• 3.6 Degradation study of CMS nanoparticles 51
• 4. Conclusions 58
• Reference 59
• 초록 64