목적: 유지 혈액투석치료를 받고 있는 만성신부전 환자에서 수반되는 우울증과 우울증상의 특성 및 정도를 조사하고, 항우울제 치료 전후의 우울증상 및 영양지표의 변화를 측정하여, 우울...
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https://www.riss.kr/link?id=A75045048
2008
-
500
SCOPUS,KCI등재,SCIE
학술저널
94-101(8쪽)
6
0
상세조회0
다운로드국문 초록 (Abstract)
목적: 유지 혈액투석치료를 받고 있는 만성신부전 환자에서 수반되는 우울증과 우울증상의 특성 및 정도를 조사하고, 항우울제 치료 전후의 우울증상 및 영양지표의 변화를 측정하여, 우울...
목적: 유지 혈액투석치료를 받고 있는 만성신부전 환자에서 수반되는 우울증과 우울증상의 특성 및 정도를 조사하고, 항우울제 치료 전후의 우울증상 및 영양지표의 변화를 측정하여, 우울증과 우울증상의 치료가 유지 혈액투석치료를 받고 있는 만성신부전 환자에게 미치는 임상적 영향을 살펴보고자 하였다. 방법: 고신대학교 복음병원 인공신장실에서 6개월 이상 동안 유지 혈액투석치료를 받고 있는 만성신부전 환자 64명을 대상으로 우울증 및 우울정도와 영양상태 지표들을 조사하였다. 주요우울증의 진단은 반구조화된 면담을 통하여 DSM-IV TR 기준을 사용하였다. 우울증상의 정도는 17문항의 Hamilton Rating Scale for Depression (HRSD)을 사용하여 측정하였다. Subjective global assessment (SGA), body mass index (BMI), triceps skin fold thickness (TSF), mid-arm muscle circimference (MAMC)와 handgrip strength를 측정하였으며 KT/V, normalized protein catabolic rate (nPCR), 혈청 알부민 농도 등과 같은 영양지표도 측정하였다. 우울증이 있는 경우 8주간의 항우울제 약물치료를 시행하였고, 치료 이후 우울증상과 영양상태의 항목들을 재평가하였다. 결과: 만성신부전으로 유지 혈액투석치료를 받고 있는 환자들 중 우울증으로 진단된 환자는 19명으로 42.2% (주요 우울장애 11명 24.4%, 기분부전장애 8명 17.8%)였다. 우울증이 있는 경우 우울한 기분, 죄책감, 자살사고, 수면장애, 일과 활동의 저하, 정신운동의 지연, 정신적 불안 및 신체 불안, 전반적인 신체증상 및 건강염려 등이 유의하게 높았다. 항우울제 약물치료 후 우울한 기분과 정신적 불안, 죄책감, 자살사고, 일과 활동, 수면장애 및 전반적인 신체증상 등이 유의하게 호전되었다. 치료 후 TSF (p<0.05), handgrip strength (p<0.01)와 hematocrit (p<0.05)이 개선되었다. 결론: 유지 혈액투석 중인 만성신부전 환자에서 우울증이 수반될 경우 우울증상에 대한 항우울제 치료는 수면과 신체증상 등을 포함하여 우울증상을 호전시킬 뿐만 아니라 삶의 질을 향상시킬 것으로 기대되므로 적극적인 항우울제 치료가 필요하다고 하겠다.
다국어 초록 (Multilingual Abstract)
Purpose: Depression is common in patients with chronic renal failure on maintenance hemodialysis, though success rate of treatment is low. This study aimed to investigate the features and severity of the depressive symptoms and nutritional indices, an...
Purpose: Depression is common in patients with chronic renal failure on maintenance hemodialysis, though success rate of treatment is low. This study aimed to investigate the features and severity of the depressive symptoms and nutritional indices, and significant changes after antidepressant treatment. Methods: The authors assessed 45 patients. Diagnosis of depression was made using DSM-IV-TR and the depressive symptoms were evaluated using Hamilton Rating Scale for Depression via semistructured interview. Subjective global assessment, anthropometric measurements and nutritional indices such as Kt/V, nPCR were examined. Depressive patients were treated for 8 weeks with SSRI (citalopram), and all the variables were examined again after the treatment. Results: 19 (42.2%) patients were diagnosed as depression. Nutritional status was not different between patients with depression and those without depression. Compared to non-depressed patients, depressed patients showed significantly higher depressed mood, guilty feeling, suicide idea, psychic and somatic anxiety, lower work and activities, psychomotor retardation, sleep disturbances, general somatic symptoms and hypochondriasis. After antidepressant treatment, depressed mood, guilty feeling, suicide idea, psychic anxiety, initial insomnia, middle insomnia, early awakening, work and activities and general somatic symptoms were improved significantly. TSF (p<0.05), handgrip strength (p<0.01) and hematocrit (p<0.05) were significantly increased. Conclusion: Antidepressant treatment is helpful not only for the improvement of depressive symptoms such as sleep and somatic symptoms but for the improvement of quality of life. Proper treatment should be more actively attempted for the hemodialytic patients with depression.
참고문헌 (Reference)
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10 Walker S, "Sleep complaints are common in a dialysis unit" 26 : 751-756, 1995
1 Chertow GM, "Vintage, nutritional status, and survival in hemodialysis patients" 57 : 1176-1181, 2000
2 Turk S, "Treatment with antidepressive drugs improved quality of life in chronic hemodialysis patients" 65 : 113-118, 2006
3 Burton HJ, "The relationship of depression to survival in chronic renal failure" 48 : 261-269, 1986
4 Hedayati SS, "The predictive value of self-report scales compared with physician diagnosis of depression in hemodialysis patients" 69 : 1662-1668, 2006
5 Leonard BE, "The immune system, depression and the action of antidepressants" 25 : 767-780, 2001
6 O'Donnell K, "The diagnosis of major depression in end-stage renal disease" 66 : 38-43, 1997
7 Watnick S, "The Prevalence and treatment of depression among patients starting dialysis" 41 : 105-110, 2003
8 Craven JL, "The Beck Depression Inventory as a screening device for major depression in renal dialysis patients" 18 : 365-374, 1988
9 Shayamsunder AK, "Sleepiness, sleeplessness, and pain in end-stage renal disease: distressing symptoms for patients" 18 : 109-118, 2005
10 Walker S, "Sleep complaints are common in a dialysis unit" 26 : 751-756, 1995
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한국인 제2형 당뇨병 환자에서 안지오텐신 전환효소 유전자 다형성과 미세알부민뇨 발생
관상동맥 조영술을 시행한 환자에서 조영제 신독성 발생에 관한 임상연구
고유량 혈액투석에서 온라인 혈액여과투석법으로 전환 후 임상 소견과 beta 2-microglobulin 및 oxidized LDL의 변화
학술지 이력
연월일 | 이력구분 | 이력상세 | 등재구분 |
---|---|---|---|
2023 | 평가예정 | 해외DB학술지평가 신청대상 (해외등재 학술지 평가) | |
2020-01-01 | 평가 | 등재학술지 유지 (해외등재 학술지 평가) | ![]() |
2011-11-29 | 학술지명변경 | 한글명 : The Korean Journal of Nephrology -> Kidney Research and Clinical Practice외국어명 : 미등록 -> Kidney Research and Clinical Practice | ![]() |
2010-01-01 | 평가 | 등재학술지 유지 (등재유지) | ![]() |
2008-01-01 | 평가 | 등재학술지 유지 (등재유지) | ![]() |
2007-02-22 | 학술지명변경 | 한글명 : 대한신장학회지 -> The Korean Society of Nephrology | ![]() |
2007-02-22 | 학술지명변경 | 한글명 : 대한신장학회지 -> The Korean Journal of Nephrology | ![]() |
2005-01-01 | 평가 | 등재학술지 선정 (등재후보2차) | ![]() |
2004-01-01 | 평가 | 등재후보 1차 PASS (등재후보1차) | ![]() |
2002-01-01 | 평가 | 등재후보학술지 선정 (신규평가) | ![]() |
학술지 인용정보
기준연도 | WOS-KCI 통합IF(2년) | KCIF(2년) | KCIF(3년) |
---|---|---|---|
2016 | 0.21 | 0.21 | 0.17 |
KCIF(4년) | KCIF(5년) | 중심성지수(3년) | 즉시성지수 |
0.14 | 0.1 | 0.422 | 0.11 |