어린이의 하악골에서 발생한 Burkitt 림프종 = BURKITT’S LYMPHOMA OF THE MANDIBLE IN A CHILD

국문 초록 (Abstract)

Burkitt 림프종은 B림프구 기원의 악성종양으로 비호지킨 림프종(non-Hodgkin’s lymphoma)의 한 종류이다. Burkitt 림프종은 임상적으로 아프리카에서 나타나는 지역형(endemic), 세계 각지에서 발생하는 산발형(sporadic), 면역결핍상태와 관련되어 나타나는 형태로 나눌 수 있다. 과거에는 그 예후가 매우 불량했으나, 최근에는 집중적인 화학요법으로 인한 치료 성공률이 50-80%에 달한다. 많은 경우 악골을 포함하고 있으며 임상증상으로는 심하게 흔들리는 치아, 치아의 변위 그리고 치은의 발적 및 부종 등이 있다. 본 증례는 진행속도가 상당히 빠른 Burkitt 림프종에 이환된 환아에 대한 내용이다. 악골에 생긴 병소로 내원하였으며, 치과에서 처음 진단하였고 신속하고 적절한 치료를 통해 양호한 결과를 얻었다.

다국어 초록 (Multilingual Abstract)

Burkitt’s lymphoma is a malignant tumor originated from B lymphocyte and a type of non-hodgkin lymphoma. It is clinically classified by endemic, sporadic and immune deficient forms. In the past, it had poor prognosis but in recent years survival rate is 50~80% treated by intensive chemotherapeutic regimens. Mostly it is a lesion of the jaws. Clinical symptoms are severe tooth mobility, displacement, gingival redness and swelling. This case is about a patient with aggressively progressing Burkitt’s lymphoma of the jaws. Initial diagnosis was done in dental hospital and it has shown satisfactory outcome by prompt and appropriate treatment.

참고문헌 (Reference)

1 최승규, "하악골에 발생한 Burkitt 임파종에 관한 연구" 22 : 973-978, 1984

2 Jan A, "Sporadic Burkitt’s lymphoma of the jaws: the essentials of prompt lifesaving referral and management" 71 : 165-168, 2005

3 Alpaslan C, "Mandibular soft tissue mass as the initial presentation of Burkitt’s lymphoma" 21 : 333-335, 1997

4 Miron I, "Initial management of advanced of Burlitt’s lymphoma in children" 14 : 555-561, 1997

5 Tsuchiya S, "Diagnosis of Epstein-Barr virus associated disease" 44 : 227-238, 2002

6 Robinson MR, "Burkitt’s/Burkitt’s-like lymphoma presenting as bacterial sinusitis in two HIV-infected children" 15 : 453-458, 2001

7 Bellan C, "Burkitt’s lymphoma: new insights into molecular pathogenesis" 56 : 188-192, 2003

8 Ferry JA, "Burkitt’s lymphoma: clinicopathologic features and differential diagnosis" 11 : 375-383, 2006

9 Lund DI, "Burkitt’s lymphoma presenting with jaw lesions in a young white girl" 35 : 438-441, 1997

10 Tsui SH, "Burkitt’s lymphoma presenting as mandibular swelling- report of a case and review of publication" 38 : 8-11, 2000

11 Afolabi C, "Burkitt’s lymphoma of the jaws: role of dental practitioner in management" 11 : 89-93, 2004

12 Tomomi H, "Burkitt’s lymphoma involving the mandible - Report of a case and review of Japanese cases" 85 : 216-220, 1998

13 Shapira J, "Burkitt's lymphoma" 34 : 15-23, 1998

14 Yustein JT, "Biology and treatment of Burkitt’s lymphoma" 14 : 375-381, 2007

15 Adde M, "Additional chemotherapeutic agents improve treatment outcome for children and adults with advanced B-cell lymphomas" 25 : 33-39, 1998

16 Burkitt D, "A sarcoma involving the jaws in African children" 46 : 218-223, 1958

17 Hupp JR, "A review of Burkitt's lymphoma. Importance of radiographic diagnosis" 10 : 240-245, 1982