46,XX True hermaphroditism is a clinical condition in which both ovarian and testicular tissues can be observed in a person. Cases of psychoses in true hermaphrodites have been rarely reported in the whole world.
Recently, we experienced a rare case...
46,XX True hermaphroditism is a clinical condition in which both ovarian and testicular tissues can be observed in a person. Cases of psychoses in true hermaphrodites have been rarely reported in the whole world.
Recently, we experienced a rare case of psychosis in a 24 year-old female who was born with ambiguous genitalia and had been confirmed as a true hermaphrodite by chromosomal analysis. This case was reported and related articles were reviewed.
The patient was raised as a boy until her male genitalia was castrated and she was raised as a girl at the beginning of the 3rd grade of her elementary school period. She was adapted well until she failed the teachers' employment examination just after graduation of her college.
Clinical features of religious delusions, bizarre behavior, self-harm, incoherent speech, sudden catatonic posturing, mutism, negativism were observed as well as transient cognitive deficit such as disorientation and loss of memory. Physical anomalies such as microcephaly, long extremity bones and ambiguous genitalia in addition to the chromosomal study of 46,X-X, +dert(X;?) suggest true hermaphroditism.
The case of a psychosis in true hermaphroditism supports the notion that sex
chromosomal anomalies may be partly involved in the pathogenesis of schizophrenia.