한공각화증과 광선각화증에서 세포사멸과 p53, bcl-2, PCNA 및 iNOS 발현에 관한 연구 (제1보) = The Preliminary Study of Apoptosis and Expression of p53, bcl-2, PCNA and iNOS in Porokeratosis and Actinic Keratosis한공각화증과 광선각화증에서 세포사멸과 p53, bcl-2, PCNA 및 iNOS 발현에 관한 연구 (제1보)

다국어 초록 (Multilingual Abstract)

Background：Porokeratosis is characterized by cornoid lamellae histologically and evolve cutaneous malignant tumors in about 7% of the patients. Actinic keratosis is the most common premalignant lesion and progressed into squamous cell carcinoma in 20% of the patients. It has been reported that the expression of p53 increased within or beneath the cornoid lamellae of porokeratosis and actinic keratosis.
Objective：The purpose of this study was to understand the role of apoptosis in pathogenesis and progression into malignant tumors and to investigate whether a positive correlation occurs between apoptosis index and expression of p53, bcl-2, PCNA and iNOS in porokeratosis and actinic keratosis.
Methods：TUNEL staining and immunohistochemical staining with p53, bcl-2, PCNA and iNOS antibody were done in paraffin-embedded tissue sections of 10 cases of porokeratosis and 12 cases of actinic keratosis.
Results：The results are summarized as follow:
1. The mean of apoptosis index(%) was 27.3±7.82 in porokeratosis, 36.3±10.32 in cornoid lamellae of porokeratosis.
2. The mean of apoptosis index(%) of actinic keratosis was 41.5±8.98 and statistically significant higher than that of porokeratosis(p=0.002). (Korean J Dermatol 2000;38(2)：207~212)