Background:Porokeratosis is characterized by cornoid lamellae histologically and evolve cutaneous malignant tumors in about 7% of the patients. Actinic keratosis is the most common premalignant lesion and progressed into squamous cell carcinoma in 2...
Background:Porokeratosis is characterized by cornoid lamellae histologically and evolve cutaneous malignant tumors in about 7% of the patients. Actinic keratosis is the most common premalignant lesion and progressed into squamous cell carcinoma in 20% of the patients. It has been reported that the expression of p53 increased within or beneath the cornoid lamellae of porokeratosis and actinic keratosis.
Objective:The purpose of this study was to understand the role of apoptosis in pathogenesis and progression into malignant tumors and to investigate whether a positive correlation occurs between apoptosis index and expression of p53, bcl-2, PCNA and iNOS in porokeratosis and actinic keratosis.
Methods:TUNEL staining and immunohistochemical staining with p53, bcl-2, PCNA and iNOS antibody were done in paraffin-embedded tissue sections of 10 cases of porokeratosis and 12 cases of actinic keratosis.
Results:The results are summarized as follow:
1. The mean of apoptosis index(%) was 27.3±7.82 in porokeratosis, 36.3±10.32 in cornoid lamellae of porokeratosis.
2. The mean of apoptosis index(%) of actinic keratosis was 41.5±8.98 and statistically significant higher than that of porokeratosis(p=0.002). (Korean J Dermatol 2000;38(2):207~212)