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      렛트에서 단기간의 갑상선 기능 변화에 따른 혈중 렙틴 농도의 변화 = Changes in Plasma Leptin Levels Relating to Short-Term Thyroid Manipulation in Rats

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      https://www.riss.kr/link?id=A19741471

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      다국어 초록 (Multilingual Abstract)

      Background: Leptin, an adipocyte derived hormone, and thyroid hormone have similar effects on energy homeostasis, such that a shortage of both hormones is associated with decreased energy expenditure and increased body weight. Therefore, for the maintenance of energy homeostasis may require a close interaction between leptin and thyroid hormone. This study was performed to investigate the change in plasma leptin levels relating to short-term thyroid manipulation causing no significant change in body weight.
      Methods: Hypothyroidism was induced by surgical thyroidectomy and hyperthyroidism by subcutaneous injection of 50 g of L-T_3/100 g body weight/day, for 5 days, in 6∼8 weeks old male Wistar rats. Body weights and food intakes were monitored daily until sacrifice. Plasma samples were collected, and the thyroid stimulating hormone (TSH), free triiodothyronine (T_3) and leptin levels measured. The plasma leptin levels in rats with hypothyroidism and hyperthyroidism were compared with those of body weights at death and food intakes during the study, atched controls.
      Results: The rats treated with L-T_3 consumed equal amount of food as freely fed, rats but their final body weights were significantly lower (L-T_3 treated 220.0±1.8 vs. freely fed 226.0±2.0 g, p<0.05). There was no difference in food intake during study, and final body weight, between the thyroidectomised rats and their paired controls (thyroidectomised 220.4±1.7 vs. paired 223.9±4.7g, P=NS). Plasma leptin levels in the L-T3 treated rats were significantly lower than those in freely fed rats (L-T3 treated 1.7±0.1 vs. freely fed 4.8±0.2 ng/ml, p<0.005). Conversely, the thyroidectomised rats had higher plasma leptin levels, compared to those of their paired controls (thyroidectomised 4.8±0.3 vs. paired 1.7±0.1 ng/ml, p<0.005).
      Conclusion: The Plasma leptin levels in the rats were decreased by short term hyperthyroidism, while they were increased by short term hypothyroidism. These findings suggest that thyroid hormones may affect the production or secretion of leptin
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      Background: Leptin, an adipocyte derived hormone, and thyroid hormone have similar effects on energy homeostasis, such that a shortage of both hormones is associated with decreased energy expenditure and increased body weight. Therefore, for the maint...

      Background: Leptin, an adipocyte derived hormone, and thyroid hormone have similar effects on energy homeostasis, such that a shortage of both hormones is associated with decreased energy expenditure and increased body weight. Therefore, for the maintenance of energy homeostasis may require a close interaction between leptin and thyroid hormone. This study was performed to investigate the change in plasma leptin levels relating to short-term thyroid manipulation causing no significant change in body weight.
      Methods: Hypothyroidism was induced by surgical thyroidectomy and hyperthyroidism by subcutaneous injection of 50 g of L-T_3/100 g body weight/day, for 5 days, in 6∼8 weeks old male Wistar rats. Body weights and food intakes were monitored daily until sacrifice. Plasma samples were collected, and the thyroid stimulating hormone (TSH), free triiodothyronine (T_3) and leptin levels measured. The plasma leptin levels in rats with hypothyroidism and hyperthyroidism were compared with those of body weights at death and food intakes during the study, atched controls.
      Results: The rats treated with L-T_3 consumed equal amount of food as freely fed, rats but their final body weights were significantly lower (L-T_3 treated 220.0±1.8 vs. freely fed 226.0±2.0 g, p<0.05). There was no difference in food intake during study, and final body weight, between the thyroidectomised rats and their paired controls (thyroidectomised 220.4±1.7 vs. paired 223.9±4.7g, P=NS). Plasma leptin levels in the L-T3 treated rats were significantly lower than those in freely fed rats (L-T3 treated 1.7±0.1 vs. freely fed 4.8±0.2 ng/ml, p<0.005). Conversely, the thyroidectomised rats had higher plasma leptin levels, compared to those of their paired controls (thyroidectomised 4.8±0.3 vs. paired 1.7±0.1 ng/ml, p<0.005).
      Conclusion: The Plasma leptin levels in the rats were decreased by short term hyperthyroidism, while they were increased by short term hypothyroidism. These findings suggest that thyroid hormones may affect the production or secretion of leptin

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      유사연구자 (20) 활용도상위20명

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      학술지 이력

      학술지 이력
      연월일 이력구분 이력상세 등재구분
      2023 평가예정 해외DB학술지평가 신청대상 (해외등재 학술지 평가)
      2020-01-01 평가 등재학술지 유지 (해외등재 학술지 평가) KCI등재
      2013-12-16 학술지명변경 한글명 : 대한내분비학회지 -> Endocrinology and Metabolism
      외국어명 : Endocrinology and Metabolism -> 미등록
      KCI등재
      2013-01-01 평가 등재 1차 FAIL (등재유지) KCI등재
      2010-06-28 학술지명변경 외국어명 : Journal of Korean Endocrin Society -> Endocrinology and Metabolism KCI등재
      2010-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2007-06-05 학회명변경 영문명 : The Korean Society Of Endocrinology -> Korean Endocrin Society KCI등재
      2007-06-01 학술지명변경 외국어명 : Journal of Korean Society of Endocrinology -> Journal of Korean Endocrin Society KCI등재
      2007-01-01 평가 등재학술지 선정 (등재후보2차) KCI등재
      2006-01-01 평가 등재후보 1차 PASS (등재후보1차) KCI등재후보
      2004-01-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
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      학술지 인용정보

      학술지 인용정보
      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 0.23 0.23 0.26
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0.23 0.22 0.508 0.08
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