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      헤테로 고리를 갖는 크리신 유도체의 합성 및 항염증 작용에 대한 평가 = Synthesis of Chrysin Analogs with a Heteroaryl Group and Evaluation for their Anti-inflammatory Activities

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      https://www.riss.kr/link?id=A100653039

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      다국어 초록 (Multilingual Abstract)

      Chrysin analogs with 2-heteroaryl groups were synthesized and evaluated for their inhibitory activities against
      PGE2 and NO production from LPS-induced RAW 264.7 cells. Chrysin analogs were synthesized from 2-hydroxy-4,6-
      dimethoxy-acetophenone and heteroaryl aldehydes in 3 steps. The tested chrysin analogs showed decreased inhibitory activity against PGE2 and NO production than those of chrysin.
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      Chrysin analogs with 2-heteroaryl groups were synthesized and evaluated for their inhibitory activities against PGE2 and NO production from LPS-induced RAW 264.7 cells. Chrysin analogs were synthesized from 2-hydroxy-4,6- dimethoxy-acetophenone and ...

      Chrysin analogs with 2-heteroaryl groups were synthesized and evaluated for their inhibitory activities against
      PGE2 and NO production from LPS-induced RAW 264.7 cells. Chrysin analogs were synthesized from 2-hydroxy-4,6-
      dimethoxy-acetophenone and heteroaryl aldehydes in 3 steps. The tested chrysin analogs showed decreased inhibitory activity against PGE2 and NO production than those of chrysin.

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      참고문헌 (Reference)

      1 Park, H, "Synthesis and inhibition of PGE2 production of 6,8-disubstituted chrysin derivatives" 40 : 943-, 2005

      2 Tran Thanh Dao, "Synthesis and Biological Activities of 8-Arylflavones" 대한약학회 27 (27): 278-282, 2004

      3 Liang, Y.-C., "Supression of inducible cyclooxygenase and nitric oxide synthase through activation of peroxisome proliferatoractivated receptor-γ by flavonoids in mouse macrophages" 496 : 12-, 2001

      4 Santosh Kumar GURUNG, "Structural Alterations of Wogonin Significantly Reduce the Inhibitory Activity against COX-2 Catalyzed PGE2 Production from LPS-Induced RAW 264.7 Cells" 한국응용약물학회 17 (17): 418-421, 2009

      5 Pearce, F. L., "Mucosal mast cells. III. Effect of quercetin and other flavonoids on antigeninduced histamine secretion from rat intestinal mast cells" 73 : 819-, 1984

      6 Santosh K. Gurung, "Inhibition of Prostaglandin E2 Production by Synthetic Wogonin Analogs" 대한약학회 32 (32): 1503-1508, 2009

      7 Hecker, M., "Inhibition by antioxidants of nitric oxide synthase expression in murine macrophages: role of nuclear factor kappa B and interferon regulatory factor 1" 118 : 2178-, 1996

      8 Habtemariam, S, "Flavonoids as inhibitors or enhancers of the cytotoxicity of tumor necrosis factor-a in L-929 tumor cells" 60 : 775-, 1997

      9 Fishkin, R. J, "Endotoxin-induced reduction of social investigation by mice: interation with amphetamine and anti-inflammatory drugs" 132 : 335-, 1997

      10 Chi, Y. S., "Effects of wogonin, a plant flavone from Scutellaria radix, on the suppression of cyclooxygenase-2 and the induction of inducible nitric oxide synthase in LPS-treated RAW 264.7 cells" 61 : 1195-, 2001

      1 Park, H, "Synthesis and inhibition of PGE2 production of 6,8-disubstituted chrysin derivatives" 40 : 943-, 2005

      2 Tran Thanh Dao, "Synthesis and Biological Activities of 8-Arylflavones" 대한약학회 27 (27): 278-282, 2004

      3 Liang, Y.-C., "Supression of inducible cyclooxygenase and nitric oxide synthase through activation of peroxisome proliferatoractivated receptor-γ by flavonoids in mouse macrophages" 496 : 12-, 2001

      4 Santosh Kumar GURUNG, "Structural Alterations of Wogonin Significantly Reduce the Inhibitory Activity against COX-2 Catalyzed PGE2 Production from LPS-Induced RAW 264.7 Cells" 한국응용약물학회 17 (17): 418-421, 2009

      5 Pearce, F. L., "Mucosal mast cells. III. Effect of quercetin and other flavonoids on antigeninduced histamine secretion from rat intestinal mast cells" 73 : 819-, 1984

      6 Santosh K. Gurung, "Inhibition of Prostaglandin E2 Production by Synthetic Wogonin Analogs" 대한약학회 32 (32): 1503-1508, 2009

      7 Hecker, M., "Inhibition by antioxidants of nitric oxide synthase expression in murine macrophages: role of nuclear factor kappa B and interferon regulatory factor 1" 118 : 2178-, 1996

      8 Habtemariam, S, "Flavonoids as inhibitors or enhancers of the cytotoxicity of tumor necrosis factor-a in L-929 tumor cells" 60 : 775-, 1997

      9 Fishkin, R. J, "Endotoxin-induced reduction of social investigation by mice: interation with amphetamine and anti-inflammatory drugs" 132 : 335-, 1997

      10 Chi, Y. S., "Effects of wogonin, a plant flavone from Scutellaria radix, on the suppression of cyclooxygenase-2 and the induction of inducible nitric oxide synthase in LPS-treated RAW 264.7 cells" 61 : 1195-, 2001

      11 Che, H, "A chrysin analog exhibited strong inhibitory activities against both PGE2 and NO production" 46 : 4657-, 2011

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      학술지 이력

      학술지 이력
      연월일 이력구분 이력상세 등재구분
      2027 평가예정 재인증평가 신청대상 (재인증)
      2021-01-01 평가 등재학술지 유지 (재인증) KCI등재
      2018-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2015-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2011-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2009-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2007-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2004-01-01 평가 등재학술지 선정 (등재후보2차) KCI등재
      2003-01-01 평가 등재후보 1차 PASS (등재후보1차) KCI등재후보
      2002-01-01 평가 등재후보학술지 유지 (등재후보1차) KCI등재후보
      1999-07-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
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      학술지 인용정보

      학술지 인용정보
      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 0.2 0.2 0.22
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0.23 0.18 0.403 0.02
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