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      Case Reports : Treatment of Keratoacanthoma with 5% Imiquimod Cream and Review of the Previous Report = Case Reports : Treatment of Keratoacanthoma with 5% Imiquimod Cream and Review of the Previous Report

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      https://www.riss.kr/link?id=A82668133

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      다국어 초록 (Multilingual Abstract)

      Keratoacanthoma (KA) is a benign epidermal tumor, characterized by rapid and abundant growth, a tendency toward spontaneous regression and histopathologic similarity to squamous cell carcinoma (SCC). Because KA can be easily misdiagnosed as SCC, surgery is considered the treatment of choice. Recently, regression of KAs following application of 5% imiquimod cream (Aldara(R)) has been reported. We present 4 cases of KA treated with topical imiquimod, applied 3 to 4 times a week. Obvious improvement was observed after 4 to 6 weeks of application and the lesions were almost cleared leaving scars after 9 to 11 weeks. These results show that topical imiquimod can be an effective option for the conservative management of KA as previously reported. We also suggest that lesions treated with imiquimod cream should be considered for biopsy to judge histopathological remission after 5 to 8 weeks of application to shorten the duration of the treatment.
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      Keratoacanthoma (KA) is a benign epidermal tumor, characterized by rapid and abundant growth, a tendency toward spontaneous regression and histopathologic similarity to squamous cell carcinoma (SCC). Because KA can be easily misdiagnosed as SCC, surge...

      Keratoacanthoma (KA) is a benign epidermal tumor, characterized by rapid and abundant growth, a tendency toward spontaneous regression and histopathologic similarity to squamous cell carcinoma (SCC). Because KA can be easily misdiagnosed as SCC, surgery is considered the treatment of choice. Recently, regression of KAs following application of 5% imiquimod cream (Aldara(R)) has been reported. We present 4 cases of KA treated with topical imiquimod, applied 3 to 4 times a week. Obvious improvement was observed after 4 to 6 weeks of application and the lesions were almost cleared leaving scars after 9 to 11 weeks. These results show that topical imiquimod can be an effective option for the conservative management of KA as previously reported. We also suggest that lesions treated with imiquimod cream should be considered for biopsy to judge histopathological remission after 5 to 8 weeks of application to shorten the duration of the treatment.

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      참고문헌 (Reference)

      1 Ko NY, "Treatment of keratoacanthoma with 5% imiquimod cream" 18 : 14-17, 2006

      2 Dendorfer M, "Topical treatment with imiquimod may induce regression of facial keratoacanthoma" 13 : 80-82, 2003

      3 Calista D, "Topical imiquimod for the treatment of keratoacanthomas" 18 : 590-591, 2008

      4 Di Lernia V, "Spontaneous regression of keratoacanthoma can be promoted by topical treatment with imiquimod cream" 18 : 626-629, 2004

      5 Yoshikawa K, "Relative amounts of keratin 17 are higher than those of keratin 16 in hair-folliclederived tumors in comparison with nonfollicular epithelial skin tumors" 104 : 396-400, 1995

      6 Vergara A, "Multiple and relapsing keratoacanthomas developing at the edge of the skin grafts site after surgery and after radiotherapy" 33 : 994-996, 2007

      7 Karaa A, "Keratoacanthoma: a tumor in search of a classification" 46 : 671-678, 2007

      8 Schwartz RA, "Keratoacanthoma: a clinico-pathologic enigma" 30 : 326-333, 2004

      9 Beham A, "Keratoacanthoma: a clinically distinct variant of well differentiated squamous cell carcinoma" 5 : 269-280, 1998

      10 Griffiths RW, "Keratoacanthoma observed" 57 : 485-501, 2004

      1 Ko NY, "Treatment of keratoacanthoma with 5% imiquimod cream" 18 : 14-17, 2006

      2 Dendorfer M, "Topical treatment with imiquimod may induce regression of facial keratoacanthoma" 13 : 80-82, 2003

      3 Calista D, "Topical imiquimod for the treatment of keratoacanthomas" 18 : 590-591, 2008

      4 Di Lernia V, "Spontaneous regression of keratoacanthoma can be promoted by topical treatment with imiquimod cream" 18 : 626-629, 2004

      5 Yoshikawa K, "Relative amounts of keratin 17 are higher than those of keratin 16 in hair-folliclederived tumors in comparison with nonfollicular epithelial skin tumors" 104 : 396-400, 1995

      6 Vergara A, "Multiple and relapsing keratoacanthomas developing at the edge of the skin grafts site after surgery and after radiotherapy" 33 : 994-996, 2007

      7 Karaa A, "Keratoacanthoma: a tumor in search of a classification" 46 : 671-678, 2007

      8 Schwartz RA, "Keratoacanthoma: a clinico-pathologic enigma" 30 : 326-333, 2004

      9 Beham A, "Keratoacanthoma: a clinically distinct variant of well differentiated squamous cell carcinoma" 5 : 269-280, 1998

      10 Griffiths RW, "Keratoacanthoma observed" 57 : 485-501, 2004

      11 Yuge S, "Keratoacanthoma centrifugum marginatum: response to topical 5-fluorouracil" 54 (54): 218-219, 2006

      12 Seifert A, "Keratoacanthoma and its clinical variants. Review of the literature and histopathologic analysis of 90 cases" 40 : 189-202, 1989

      13 Annest NM, "Intralesional methotrexate treatment for keratoacanthoma tumors: a retrospective study and review of the literature" 56 : 989-993, 2007

      14 Paternò EJ, "Imiquimod for restoring local immunity in a renal transplant patient with persistent keratoacanthoma" 14 : 8-, 2008

      15 Bhatia N, "Imiquimod as a possible treatment for keratoacanthoma" 3 : 71-74, 2004

      16 김용주, "Imiquimod 5% 크림으로 치료한 각화극세포종 1예" 대한피부과학회 42 (42): 1321-1324, 2004

      17 Kwittken J, "A histologic chronology of the clinical course of the keratocarcinoma (so-called keratoacanthoma)" 42 : 127-135, 1975

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      연월일 이력구분 이력상세 등재구분
      2023 평가예정 해외DB학술지평가 신청대상 (해외등재 학술지 평가)
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      2016 1.11 0.23 0.72
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0.67 0.48 0.376 0.03
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