무증상 뇌경색의 위험요인에 대한 환자;대조군 연구 = The Case-Control Study of Risk Factors of Silent Cerebral Infarction

다국어 초록 (Multilingual Abstract)

Background : Cerebrovascular disease is a major cause of death and disability in adults. Silent cerebral infarction (SCI) portends more severe cerebral infarction or may lead to insidious progressive brain damage resulting in vascular dementia. Known cardiovascular risk factors, such as arterial hypertension, diabetes mellitus, smoking, hyperlipidemia and ischemic heart disease may increase the risk of SCI. This study was designed to evaluate the risk factors of SCI in an apparently normal adult population. Methods : We divided 340 neurologically normal adults (mean age=59.90$\pm$8.30, men:women = 146:194) who underwent brain computed tomography (CT) or magnetic resonance imaging (MRI) at the Stroke Medical Center in Daejeon University Oriental Medicine Hospital in two groups, Silent inf. and Controls,and analyzed risk factors of SCI by interview, physical examination and blood test. Risk factors of SCI were assessed by interview, physical examination and blood test. We performed Pearson's chi-square test and two-sample t-test for univariate analysis and multiple logistic regressions for multivariate analysis to evaluate risk factors of SCI. Results : Old age, diabetes mellitus, and high lactate dehydrogenase (LDH) levels were associated with SCI on univariate analysis. Diabetes mellitus was demonstrated to be an independent risk factor for SCI on multivariate analysis. Conclusions : Advanced age, diabetes mellitus, and LDH levels are associated with SCI.

참고문헌 (Reference)

1 오용성, "중풍환자 125예에 대한 임상적 고찰" 27 (27): 15-26, 2002

2 황민우, "사상체질에 따른 허혈성 뇌졸중 환자-대조군 연구" 27 (27): 118-129, 2006

3 최재영, "四象醫學的 中風治驗 157예에 대한 臨床的 硏究" 10 (10): 431-453, 1998

4 Hijdra A, "van Gijn J. Silent stroke in patients with transient ischemic attack or minor ischemic stroke" 1220-4,

5 "WHO Western Pacific Region, International Association for the Study of Obesity, International Obesity Task Force. The Asia-Pacific perspective; redefining obesity and its treatment. Australia" Australia. Health Communications 2000

6 Cheong BS, "The clinical study of risk and lifestyle factors in stroke" 18 (18): 14-26, 2001

7 Yu BC, "The case-control study on the risk factors and presymptoms of each stroke type" 2007

8 Kobayashi S, "Subcortical silent brain infarction as a risk factor for clinical stroke" 28 : 1932-1939, 1997

9 Masuda J, "Silent stroke; pathogenesis, genetic factors and clinical implications as a risk factor" 14 : 77-82, 2001

10 Yoon SK, "Silent brain infarcts in first-ever ischemic stroke patients; MRI findings and stroke risk factors" 14 : 42-45, 1996

11 Bernick C, "Silent MRI infarcts and the risk of future stroke; the cardiovascular health study" 57 : 1222-1229, 2001

12 Kase CS, "Scampini L. Prevalence of silent stroke in patients presenting with intial stroke" 850-2,

13 Uehara T, "Risk factors for silent cerebral infarcts in subcortical white matter and basal ganglia" 30 : 378-382, 1999

14 Feigin VL, "Risk factors for ischeemic stroke in a Russian community; a population -based case-control study" 29 : 34-39, 1998

15 Wong KS, "Risk factors for early death in acute ischemic stroke and intracerebral hemorrhage ; a prospective hospital-based study in Asia; Asian Acute Stroke Advisory PanelRisk factors for early death in acute ischemic stroke and intracerebral hemorrhage ; a prospective hospital-based study in Asia; Asian Acute Stroke Advisory Panel" 30 : 2326-2330, 1999

16 Shim DS, "Prevalence and risk factors of silent cerebral infarction in normal adults-single institute study" 23 : 303-306, 2005

17 Lee SC, "Prevalence and risk factors of silent cerebral infarction in apparently normal adults" 36 : 73-77, 2000

18 Vermeer SE, "Prevalence and risk factors of silent brain infarcts in the population-based Rotterdam Scan Study" 33 : 21-25, 2002

19 Vermeer SE, "Incidence and risk factors of silent brain infarcts in the population-based Rotterdam Scan Study" 34 : 392-396, 2003

20 Foulkes MA, "Furtado JG. Silent stroke in the NINCDS Stroke Data Bank. Neurolgy. 1988" 1674-9,

21 Milionis HJ, "Fisk factors for first-ever acute ischemic non- embolic stroke in elderly individuals" 99 : 269-275, 2005

22 Jia WP, "Epidemiology study on obesity and its comorbidities in urban Chinese older than 20 years of age in Shanghai. China" 3 : 157-165, 2002

23 Matsui T, "Elevated plasma homocysteine levels and risk of silent brain infarction in elderly people" 32 : 1116-1119, 2001

24 Ko SG, "Development of CRF and SOPs for the identification of risk factors of the cerebrovascular disease in the east and west medicine" 27 (27): 204-219, 2006

25 Choi SH, "Cut-off value of waist circumference for metabolic syndrome patients in Korea adult population" 13 (13): 53-60, 2004

26 Sun JJ, "Comparison study on the characteristics among sasang constitution in acute stroke patients" 28 (28): 34-46, 2007

27 Lee KN, "Clinincal pathology file" Seoul: Eui-Hak publishing 3rd ed : 373-374, 2003

28 Cho KH, "Chunghyul -dan for the prevention of stroke progression in silent brain infarction" 26 (26): 77-84, 2005

29 Ricci S, "Caputo N. Silent brain infarctions in patients with first-ever stroke a community -based study in Umbria" 647-51,

30 North American Symptomatic Endarterecomy Trial, "Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. N. Engl. J. Med. 1991" 445-53,

31 Kim SH, "A study on the standardization of Questionnaire for the Sasang Constitution Classification Ⅱ(QSCC Ⅱ)" 17 (17): 337-393, 1996

32 Kim FR, "A hospital -based case-control study on the risk factors of cerebrovascular disease" 28 (28): 473-486, 1995