Role of C-type Natriuretic Peptide in Linear Growth

다국어 초록 (Multilingual Abstract)

The natriuretic peptides are a family of three peptides, atrial natriuretic peptide (ANP),brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP). CNP is produced in the growth plate and acts in a paracrine/autocrine manner and has been found to play an essential role in enchondral bone growth , as demonstrated in rodents and human. Biosynthetic processing of CNP releases a bioinactive amino-terminal propeptide of C-type natriuretic peptide (NTproCNP) and is produced in equimolar amounts with CNP. The level of NTproCNP in plasma reflects the rate of CNP biosynthesis and measured easily using commercial kit by enzyme-linked immunosorbent assay (ELISA)method. Knockout mice for CNP or its cognate receptor (NPR-B) are dwarfed. In human,homozygous loss of functional mutations in the NPR-B gene causes acromesomelic dysplasia, Maroteaux type (OMIM #602875). To clarify the role of CNP/NTproCNP in linear growth in human, some researchers measured plasma NTproCNP levels in healthy children and children with short stature due to various causes. CNP showed the heighest levels after 12 hr of life and with a progressive decline afterwards. It is proved that there is modest but significant correlation between NTproCNP level and IGF-I in healthy children and the timing of peaks in NTproCNP and IGF-I were identical in both sex.
This paper will introduce recent advances of researches concerning about the role of CNP/NTproCNP in human growth in children with various conditions and suggest the future direction of this promising study field.

참고문헌 (Reference)

1 Yasoda A, "Systemic administration of C-type natriuretic peptide as a novel therapeutic strategy for skeletal dysplasia" 150 : 3138-3144, 2009

2 Koller KJ, "Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP)" 252 : 120-123, 1991

3 Sellitti DF, "Regulation of C-type natriuretic peptide expression" 32 : 1964-1971, 2011

4 Hyun SE, "Reference values for serum levels of insulin-like growth factor-I and insulin-like growth factor binding protein-3 in Korean children and adolescents" 45 : 16-21, 2012

5 Suga S, "Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide" 130 : 229-239, 1992

6 Suga S, "Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide" 130 : 229-239, 1992

7 Stingo AJ, "Presence of C-type natriuretic peptide in cultured human endothelial cells and plasma" 263 : 1318-, 1992

8 Nelesen RA, "Plasma atrial natriuretic peptide is unstable under most storage conditions" 86 : 463-468, 1992

9 Prickett TCR, "Plasma amino-terminal pro C-type natriuretic peptide in the neonate: relation to gestational age and postnatal linear growth" 93 : 225-232, 2008

10 Del Ry S, "Plasma C-type natriuretic peptide levels in healthy children" 33 : 83-86, 2012

11 Maack T, "Physiological role of silent receptors of atrial natriuretic factor" 238 : 675-678, 1987

12 Yasoda A, "Overexpression of CNP in chondrocytes rescues achondroplasia through a MASK-dependent pathway" 10 : 80-86, 2004

13 Argente J, "Normative data for insulin-like growth factors (IGFs), IGF-binding proteins, and growth hormone-binding protein in a healthy Spanish pediatric population: age- and sex-relatd changes" 77 : 1522-1528, 1993

14 Wodard GE, "Natriuretic peptides in vascular physiology and pathology" 268 : 59-93, 2008

15 Totsune K, "Natriuretic peptides in the human kidney" 24 : 758-762, 1994

16 Levin ER, "Natriuretic peptides" 339 : 321-328, 2010

17 Yasoda A, "Natriuretic peptide regulation of endochondral ossification. Evidence for possible roles of the C-type natriuretic peptide/guanylyl cyclase-B pathway" 273 : 11695-11700, 1998

18 Bartels CF, "Mutations in the transmembrane natriuretic peptide receptor NPR-B impair skeletal growth and cause acromesomelic dysplasia, type Maroteaux" 75 : 27-34, 2004

19 Yasue H, "Localization and mechanism of secretion of B-type natriuretic peptide in comparison with those of A-type natriuretic peptide in normal subjects and patients with heart failure" 90 : 195-203, 1994

20 Totsune K, "Immunoreactive C-type natriuretic peptide in human adrenal glands and adrenal tumors" 15 : 287-290, 1994

21 박주현, "Hundreds of variants clustered in genomic loci and biological pathways affect human height" NATURE PUBLISHING GROUP 467 (467): 832-838, 201010

22 Zhang M, "Granulosa cell ligand NPCC and its receptor NPR2 maintain meiotic arrest in mouse oocytes" 330 : 366-369, 2010

23 Wu C, "Furin-mediated processing of Pro-C-type natriuretic peptide" 278 : 25847-25852, 2003

24 Chusho H, "Dwarfism and early death in mice lacking C-type natriuretic peptide" 98 : 4016-4021, 2001

25 Suga S, "Cytokine induced C-type natriuretic peptide (CNP) secretion from vascular endothelial cells -evidence for CNP as a novel autocrine/paracrine regulation from endothelial cells" 133 : 3038-3041, 1993

26 Tamura N, "Critical roles of the guanylyl cyclase B receptor in endochondral ossification and development of female reproductive organs" 101 : 17300-17305, 2004

27 Kake T, "Chronically elevated plasma C-type natriuretic peptide level stimulates skeletal growth in transgenic mice" 297 : 1339-1348, 2009

28 Chrisman TD, "Characterization of particulate and soluble guanylate cyclases from rat lung" 250 : 374-381, 1975

29 Prickett TCR, "C-type natriuretic peptide: a novel biomarker of steroid induced bone toxicity in children with acute lymphoblastic leukemia (ALL)" 36 : 54-59, 2012

30 Xia W, "C-type natriuretic peptide regulates blood-testis barrier dynamics in adult rat testes" 104 : 3841-3846, 2007

31 Olney RC, "C-type natriuretic peptide in growth: a new paradigm" 16 : 6-14, 2006

32 Sudoh T, "C-type natriuretic peptide (CNP): a new member of the natriuretic peptide family identified in porcine brain" 168 : 863-870, 1990

33 Sudoh T, "C-type natriuretic peptide (CNP): a new member of natriuretic peptide family identified in porcine brain" 168 : 863-870, 1990

34 Komatsu Y, "C-type natriuretic peptide (CNP) in rats and humans" 129 : 1104-1106, 1991

35 Tremblay J, "Biochemistry and physiology of the natriuretic peptide receptor guanylyl cyclases" 230 : 31-47, 2002

36 Needleman P, "Atriopeptin: A cardiac hormone intimately involved in fluid, electrolyte, and blood pressure homeostasis" 314 : 828-834, 1986

37 Edwards BS, "Atrial stretch, not pressure, is the principle determinant controlling the acute release of atrial natriuretic peptide" 62 : 191-195, 1988

38 Olney RC, "Aminoterminal propepetide of C-type natriuretic peptide(NTproCNP) predicts height velocity in healthy children" 77 : 416-422, 2012

39 Olney RC, "Amino-Terminal propeptide of C-type natiuretic peptide and linear growth in children: Effects of puberty, testosterone, and growth hormone" 92 : 4294-4298, 2007

40 Tomer Y, "A rapid and potent natriuretic peptide response to intravenous injection of atrial myocardial extract in rats" 28 : 89-94, 1981

41 Sudoh T, "A new natriuretic peptide in human brain" 332 : 78-81, 1988