모싯잎의 난소절제 생쥐에 대한 골다공증 조절 효과

국문 초록 (Abstract)

난소절제에 의하여 유도된 생쥐 골다공증 모델을 이용하여 모싯잎 분말과 모싯잎 추출물의 골다공증에 대한 효과를 관찰하고자 농도별 모싯잎 분말과 모싯잎 추출물을 12주간 자유 섭취 또는 경구투여 하였다. 실험종료 후 micro-CT를 이용하여 경골의 골밀도, 구조적인 변수들 및 골 형성과 골흡수 관련 인자들인 혈청 내 osteocalcin 함량과 CTX-1의 변화를 관찰하였다. 모싯잎 분말 급여군과 모싯잎 추출물 투여군은 12주째에 실험적 골다공증 모델 생쥐의 혈청 내 골 형성 인자와 골 흡수 인자를 감소시켰으며, 골밀도 등골다공증 관련 치밀뼈와 해면뼈의 구조적 변수들을 개선한 것으로 보아 골다공증 예방에 매우 효과적인 기능성 식품으로 활용할 수 있으리라 생각된다.

다국어 초록 (Multilingual Abstract)

The objectives of this study were to investigate the effects of Ramie leaves (RL) on bone metabolism in ovariectomized (OVX) mice. Female mice weighing 20∼25 g each were assigned to six experimental groups: Sham-operated group (Sham group), OVX control group (OVX group), OVX mice fed calcium-free diet with 5% (RL5% group) or 10% (RL10% group) RL supplemented diet, and administered ramie extract (RLext group, 1,000 mg/kg, p.o.). After 12 weeks, all experimental groups demonstrated significantly increased bone mineral density and trabecular thickness, and the RL10% and RLext groups showed significantly increased bone volume/tissue volume and trabecular number. This study attempted to use a physiological analysis method to analyze the serum osteocalcin and C-telopeptide contents of type Ⅰ collagen (CTX-1). The osteocalcin concentration was significantly reduced in both the RL5% group (28.6%) and RL10% group (36.5%) compared to the OVX group. The CTX-1 concentration was significantly reduced in both the RL5% group (43.5%) and RL10% group (42.9%) compared to the OVX group. These results suggest that RL might improve the structural parameters of trabecular bone and bone mineral density, as well as reduce bone formation and bone resorption factors. Therefore, RL could be applied as a functional food material for prevention of osteoporosis.

목차 (Table of Contents)

• ABSTRACT
• 서론
• 재료 및 방법
• 결과 및 고찰
• 요약
• REFERENCES

참고문헌 (Reference)

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