SBY-3의 흰쥐 비만형성 억제효능에 대한 연구 = The Study for the Prohibitive Effect of SBY-3 on Obesity Formation

다국어 초록 (Multilingual Abstract)

Objective: This experimental study was designed to investigate the effect of SBY-3 extract on the body weight, plasma, UCP mRNA in obese rats. Methods: The body weight gain, weight of the internal organs(epididymis, liver, adipose tissue), insulin, triglyceride, total cholesterol, HDL-cholesterol, total lipid, free fatty acid, expression of UCP mRNA were measured in obese rats administered SBY-3 extract for 8 weeks. These were then compared with those of control groups administered physiological saline. Results: 1. In the sample group, the body weight decrease occurred significantly than that of control group(p<0.001). 2. In the sample group, epididymal fat weight showed significantly decrease than that of control group(P<0.05). 3. In the sample group, fat accumulation in liver showed significantly decrease than that of control group(P<0.001). 4. In the sample group, triglyceride, total cholesterol, total lipid, free fatty acid showed significantly decrease than that of control group(P<0.05, P<0.01). 5. In the sample group, UCP1 mRNA in BAT significantly decrease than that of control group(P<0.05).Conclusions :These results shows that SBY-3 has effects on the management of obesity.