새로운 Schiff's base의 合成에 關한 硏究 = Studies on the Synthesis of new Schiff's base

국문 초록 (Abstract)

3-formyl rifamycin SV의 functional group인 -CHO group과 D-amino-1-butanol의 -NH_2 group사이에서 새로운 Schiff's base를 合成하였다. 이 合成의 가장 좋은 條件은 兩化合物의 mole ratio가 1:1이고 20∼25℃에서 1시간 反應시키는 것이었다. 그리고 合成된 Schiff's base는 黑紫色의 結晶이었으며 그 absorption maximum은 345nm와 555nm에 있었다. 그런데 이 化合物은 매우 不安定하여서 쉽게 加水分解되어 3-formyl rifamycin SV와 D-2-amino-1-butanol로 되돌아갔다. 그러나 이 Schiff's base를 還元하면 매우 安定된 黃色結晶이 되었다. 이 還元된 結晶의 absorption maximum은 315nm와 445nm에 있었다.

다국어 초록 (Multilingual Abstract)

The new Schiff's base was synthesized from the-CHO group of 3-formyl rifamycin SV and the-NH group of D-2-amino-1-butanol.
The results were as follow:
(1) The desired compound was most effectively synthesized when it was reacted for 1 hour at 20∼25℃ and in the mole ratio 1:1 between 3-formyl rifamycin SV and D-2-amino-1-butanol.
(2) The product was dark violet crystal, very unstable, and its absorption maximum was to 345 nm, and 555 nm.
(3) At reduction of the product, it became very stable and its absorption maximum was to 315 nm and 445 nm.
(4) The new synthesized Schiff's base is regarded as 3-(1-hydroxy-2-n-butanylimino-methyl)-rifamycin SV.