In order to observe the appearance of drug resistant strains in vivo, soil acid fast bacilli (s-12) which exhibited and appearance in high frequency of drug resistant strains in vitro experiments, were inoculated into the mice, and three days after in...
In order to observe the appearance of drug resistant strains in vivo, soil acid fast bacilli (s-12) which exhibited and appearance in high frequency of drug resistant strains in vitro experiments, were inoculated into the mice, and three days after inoculation these mice were followed by treatment with streptomycin and isonicotinic amide hydrazid for 2 to 3 weeks according to the groups.
After the cessation of treatment, mice of the each group were sacrificed and the drugs treated, on both two and three weeks treated groups, with a single exception of high druges treated, on both and three weeks treated groups, with a single exception of high resistant variant from on the liver lesion of the 3 weeks treated isonicotnic amid hydrazid group.