Assessment of Left Ventricular Function by Analysis ofVolume-Time Curves of 16 Segments with Real-Time ThreeDimensional Echocardiography: Left Ventricular Asynchrony asa Clinical ...

다국어 초록 (Multilingual Abstract)

Background and Objectives：Recent technical developments with high-resolution real-time 3-dimensional echocardiography
(RT3DE) have facilitated the acquisition of high quality images and the analysis of segmental volumetime
curves (VTCs). The purposes of this study were to assess left ventricular (LV) asynchrony with using the VTCs
of 16 segments by RT3DE and to compare this with tissue Doppler imaging (TDI) as a clinical parameter. Subjects
and Methods：Twenty-three heart failure (HF) patients (LVEF: 25±6%, age: 60±13 years) and 16 normal
controls underwent TDI and RT3DE at baseline and 1-year. The standard deviation (SD3) of the end systolic
time to reach the minimal systolic volume for the 16 segments on VTCs was obtained by RT3DE. The standard
deviation (SD2) of the electromechanical coupling time for the 8 segments was measured using TDI. Results：
SD3 was markedly higher in the HF patients than that in the controls (7.7±2.5 vs 1.5±1.0%, respectively, p<
0.01) and it increased as the LVEF decreased (r=-0.85, p<0.01). SD2 was also significantly higher in the HF
patients (27.0±8.6 vs 12.6±5.0 msec, respectively, p<0.01) and it had good negative correlation with the LVEF
(r=-0.72, p<0.01). SD3 was well correlated with SD2 (r=0.66, p<0.01). At 1-year, the HF patients with an increased
LVEF showed a decreased SD3 (7/13). In contrast, the patients with a decreased LVEF had an increased
SD3 (3/13). Conclusion：The analysis of VTCs for the 16 LV segments with using RT3DE from a single acoustic
window may be a useful clinical parameter for evaluating the LV function, including LV asynchrony, the LV volume
and the LVEF. (Korean Circulation J 2006;36:669-675)

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