운동유발성 천식 환자에서 말초혈액 호염기구의 히스타민 유리능

다국어 초록 (Multilingual Abstract)

Respiratory water loss and heat loss have been proposed as important mechanisms accounting for exercise induced asthma(EIA). The cellular mechanism accounting for osmotic stimulus inducing bronchoconstriction in an asthmatic airway is not clear. Some studies have shown an increase in plasma histamine with EIA. But there is a controversy whether it is related to the increase of numbers or to the increase of histamine releasibility of peripheral basophils by exercise. In order to evaluate the change of histamine releasibility from peripheral basophils by exercise in patients with EIA, we estimated histamine release induced by anti IgE or calcium ionophore A23187 before and after exercise in 13 patients with EIA and 9 control subjects. The results are as follows: 1) The degree of % fall of FEV1 after exercise in patients with EIA showed significant correlation with log PC20 of methacholine(r=0.69), but not with basal FEV1% (r =0.39) respectively. 2) Total histamine amount of peripheral basophils was increased after exercise in accordance with increased numbers of per- ipheral basophils. 3) There was no significant difference between preexercise PC30% anti IgE of patients with EIA and control subjects. 4) There was no significant difference between preexercise PC30% anti IgE and postexercise PC30% anti IgE both in patients with EIA and control subjects. And there was also no significant difference between preexercise PC30% calcium ionophore A23187 and postexercise PC30% calcium ionophore A23187. In conclusion, bronchoconstriction induced by exercise in patients with EIA was not due to change of hitamine releasibility of peripheral basophils by exercise.