Clinical manifestations and survival rate in women with endometrial cancer according to endometriosis = Clinical manifestations and survival rate in women with endometrial cancer according to endometriosis

다국어 초록 (Multilingual Abstract)

Objective: This study aimed to evaluate clinical manifestations and survival rate according to endometriosis in Korean women with endometrial cancer using the nationwide cohort study.
Methods: We selected 11,497 women newly diagnosed with endometrial cancer between 2008 and 2016 from the Korean Health Insurance Review and Assessment Service databases. Women with endometrial cancer were defined as women with five or more diagnostic codes for endometrial cancer and no diagnostic code for any other cancer. Endometriosis was defined as presence of a diagnostic N80X code with associated procedures that included fulguration, ovarian cystectomy, adnexectomy, and hysterectomy within 60 days before or after an initial diagnostic code.
Results: The data from 2,142 women (18.6%) with endometriosis and 9,355 women (81.4%) without endometriosis were extracted for analysis. Age at diagnosis of endometrial cancer was lower in women with endometriosis compared to those without endometriosis (years, 52.3±8.9 vs 54.6±9.8, P < 0.001). Compared with women without endometriosis, frequency of those with endometriosis were higher between 30 and 49 years (37.4% vs 28.3%) and lower between 60 and 79 years (18.3% vs 28.8%). Frequencies of type 2 diabetes were not different between the groups. Adjuvant radiation therapy after surgery was performed in less frequency in women with endometriosis compared to those without endometriosis (20% vs 23.4%, P < 0.001). However, rate of adjuvant chemotherapy was not different between the groups. Moreover, overall survivals were not different between the groups.
Conclusion: Women with endometriosis occur endometrial cancer in relatively younger age. Endometriosis is not associated with survival of endometrial cancer