소양감과 전신 홍반을 동반한 Lenalidomide에 의한 약물 발진 = A Case of Lenalidomide-induced Drug Eruption Presenting as Pruritus and Erythema Covering the Whole Body

다국어 초록 (Multilingual Abstract)

Lenalidomide is an immunomodulatory drug used for the treatment of multiple myeloma. Several cases of hematological, gastrointestinal, and cutaneous side effects have been reported for this drug. A 67-year-old patient with multiple myeloma had initially been treated with bortezomib, but the treatment was discontinued due to neurological side effects. The chemotherapeutic regimen of this patient was changed to lenalidomide. Ten days later, erythema and pruritus developed on the entire body. The lenalidomide dose was subsequently reduced and the patient was additionally treated with topical steroids. Because lenalidomide is supplied by the Korean Orphan Drug Center, physicians have limited experience with the drug, and hence, its side effects tend to be underestimated. In addition, the Korean literature lacks reports on such cases. We describe herein a case of lenalidomide-induced drug eruption presenting as a pruritic rash covering the whole body. (Korean J Dermatol 2019;57(3):149∼151)

참고문헌 (Reference)

1 강정난, "항암제와 관련된 피부이상반응에 대한 고찰" 대한피부과학회 55 (55): 89-95, 2017

2 우인숙, "항암제에 의한 말초 신경병증의 최신 지견" 대한내과학회 88 (88): 35-37, 2015

3 최윤선, "몸통의 다발성 판으로 나타난 Bortezomib에 의한 약물 발진 2예" 대한피부과학회 54 (54): 47-51, 2016

4 이혜정, "다발성 골수종에서 Lenalidomide 치료 후 발생한이차성 원발 종양 1예" 대한내과학회 86 (86): 353-356, 2014

5 윤성수, "Use of lenalidomide in the management of relapsed or refractory multiple myeloma: expert recommendations in Korea" 대한혈액학회 50 (50): 7-18, 2015

6 Barley K, "Outcomes and management of lenalidomide-associated rash in patients with multiple myeloma" 57 : 2510-2515, 2016

7 Chen AP, "Grading dermatologic adverse events of cancer treatments: the common terminology criteria for adverse events version 4.0" 67 : 1025-1039, 2012

8 Imbesi S, "Cutaneous adverse reactions to lenalidomide" 43 : 88-91, 2015

9 오영준, "Bortezomib으로 유발된 Histiocytoid Sweet 증후군" 대한피부과학회 54 (54): 739-743, 2016

10 Naranjo CA, "A method for estimating the probability of adverse drug reactions" 30 : 239-245, 1981