Anti-metastatic effect of cantharidin in A549 human lung cancer cells

다국어 초록 (Multilingual Abstract)

Cancer metastasis is represented by migrationand invasion of cancer cells. Cancer cells invade into theblood or lymphatic vessels and this leads to the spread ofcancer into the organs in distant sites. For cancer cells tomigrate, extracellular matrix (ECM) must be degraded.
Cantharidin, a compound derived from blister beetles, isknown for its anti-cancer effect in several cancer cells.
Here we report that cantharidin inhibits migration andinvasion of A549 human lung cancer cell. We found thatcantharidin inhibits activation of phosphatidylinositol3-kinase/Akt signaling pathway. This leads to the selectiveattenuation of one of the gelatinases, matrix metalloproteinase2, which can degrade components of ECM, andinhibits migration and invasion of A549 human lung cancercell.

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