Anti-Inflammatory Effect of Pristimerin on Lipopolysaccharide- Induced Inflammatory Responses in Murine Macrophages

다국어 초록 (Multilingual Abstract)

Pristimerin, a quinonemethide triterpenoid derivedfrom Celastraceae and Hippocrateaceae, has recently beenfound to suppress tumor promotion, metastasis and angiogenesis.
In the present study, we evaluated the anti-inflammatorypotentials of pristimerin in a cell culture system.
Pristimerin suppressed not only the generation of nitric oxide(NO) and prostaglandin E2, but also the expression of inducibleNO synthase and cyclooxygenase-2 induced by lipopolysacharide(LPS) in murine macrophage RAW264.7 cells.
Similarly, pristimerin inhibited the release of pro-inflammatorycytokines, namely, tumor necrosis factor-a and interleukin-6, induced by LPS. The underlying mechanism of the antiinflammatoryaction of pristimerin was correlated with downregulationof nuclear factor-jB and the mitogen-activatedprotein kinase signal pathway.

참고문헌 (Reference)

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