자궁경부 세포진검사에서 인유두종 바이러스 감염의 세포학적 및 조직학적 진단의 상관성에 관한 연구 = A study about histologic correlation of HPV effect detected in cervicovaginal smear

다국어 초록 (Multilingual Abstract)

Object : This study was aimed to evaluate the histologic-cytologic correlation in cervicovaginal smears with the evidence of human papillomavirus (HPV) infection identified by HPV polymerase chain reaction (PCR).
Materials and methods : The materials consisted of 90 cases of cervicovaginal smear which was confirmed on histologic examination and HPV PCR tests. The author re-evaluated the cytologic diagnoses of all cytologic materials and compared the cytologic diagnosis with histologic diagnosis. Then, the causes of inconsistencies of histologic and cytologic diagnoses were analysed.
Results : The age distribution of the patients was 34 cases (37.8%) of the forties, 21 cases (23.3%) of the thirties, and 17 cases (18.9%) of the fifties in the order. The mean age at diagnosis was 50 years old and the range was 23 to 75 years old. The most common histologic diagnosis was moderate dysplasia to carcinoma in situ in 35 cases (38.9%). The following diagnosis was flat condyloma in 27 cases (30.0%), chronic cervicitis in 17 cases (18.9%), and invasive squamous cell carcinoma in 9 cases (10.0%) in the order. The distribution of cytologic diagnosis was benign cellular change (BCC) in 23 cases (25.6%), low squamous intraepithelial lesion (SIL) in 20 cases (22.2%), and atypical squamous cell with uncertain significance (ASCUS) and high SIL in each 19 cases (21.1%). The overall consistency rate of both histologic and cytologic diagnoses was 72.2%, and the inconsistency rate was 27.8%. The highest rate of the diagnostic inconsistency was found in low SIL as 55.5%.
Conclusion : It has been concluded that the cytologic diagnosis related to HPV-related cervical diseases was relatively excellent. However, the cytologic diagnosis of low SIL should be more cautious because of poor correlation with histologic diagnosis and common confusion from perimenopausal cytologic atypia.