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      단안 선택적 레이저섬유주성형술에서 안압 변동을 보정한 성공예측인자의 분석 = Predictors of Success of Selective Laser Trabeculoplasty Adjusted for Intraocular Pressure Variations

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      https://www.riss.kr/link?id=A105938157

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      다국어 초록 (Multilingual Abstract)

      Purpose: To investigate the efficacy, and identify predictors of success of selective laser trabeculoplasty (SLT) in open-angle glaucoma (OAG) patients after adjusting for intraocular pressure (IOP) changes in the untreated fellow eye.
      Methods: This retrospective chart review included 52 eyes of 52 OAG patients who underwent SLT in one eye and were followed- up for at least 1 year after the procedure. The IOP was measured before the treatment, at 1, 2, and 3 months posttreatment, and every 3 months thereafter. To account for the possible influence of IOP fluctuations on laser outcomes, post-laser IOP values of the treated eye of each patient were also analyzed, after adjusting for IOP changes in the untreated fellow eye. Success was defined as an IOP decrease ≥20% of the pretreatment IOP. The success rate was determined based on Kaplan-Meier survival analysis and factors predictive of success were analyzed using the Cox proportional hazard model.
      Results: The mean pretreatment IOP was 23.17 ± 6.96 mmHg. The mean IOP reduction was 5.59 ± 4.78 mmHg (29.7%) and the success rate was 65.4% at 1 year. The adjusted mean IOP reduction was 4.70 ± 4.67 mmHg (23.9%) and the adjusted success rate was 53.9%. Pretreatment IOP was associated with SLT success; the higher the pretreatment IOP, the greater the post-laser IOP reduction (p = 0.025). Age and mean deviation index did not show a significant association with SLT success (p = 0.066 and p = 0.464, respectively).
      Conclusions: SLT is a safe and effective alternative method of IOP reduction in OAG patients. Herein, pretreatment IOP was the only factor significantly associated with SLT success. IOP fluctuations of the untreated eye should be considered for a better understanding of the impact of treatment.
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      Purpose: To investigate the efficacy, and identify predictors of success of selective laser trabeculoplasty (SLT) in open-angle glaucoma (OAG) patients after adjusting for intraocular pressure (IOP) changes in the untreated fellow eye. Methods: This ...

      Purpose: To investigate the efficacy, and identify predictors of success of selective laser trabeculoplasty (SLT) in open-angle glaucoma (OAG) patients after adjusting for intraocular pressure (IOP) changes in the untreated fellow eye.
      Methods: This retrospective chart review included 52 eyes of 52 OAG patients who underwent SLT in one eye and were followed- up for at least 1 year after the procedure. The IOP was measured before the treatment, at 1, 2, and 3 months posttreatment, and every 3 months thereafter. To account for the possible influence of IOP fluctuations on laser outcomes, post-laser IOP values of the treated eye of each patient were also analyzed, after adjusting for IOP changes in the untreated fellow eye. Success was defined as an IOP decrease ≥20% of the pretreatment IOP. The success rate was determined based on Kaplan-Meier survival analysis and factors predictive of success were analyzed using the Cox proportional hazard model.
      Results: The mean pretreatment IOP was 23.17 ± 6.96 mmHg. The mean IOP reduction was 5.59 ± 4.78 mmHg (29.7%) and the success rate was 65.4% at 1 year. The adjusted mean IOP reduction was 4.70 ± 4.67 mmHg (23.9%) and the adjusted success rate was 53.9%. Pretreatment IOP was associated with SLT success; the higher the pretreatment IOP, the greater the post-laser IOP reduction (p = 0.025). Age and mean deviation index did not show a significant association with SLT success (p = 0.066 and p = 0.464, respectively).
      Conclusions: SLT is a safe and effective alternative method of IOP reduction in OAG patients. Herein, pretreatment IOP was the only factor significantly associated with SLT success. IOP fluctuations of the untreated eye should be considered for a better understanding of the impact of treatment.

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      국문 초록 (Abstract)

      목적: 선택적 레이저섬유주성형술(selective laser trabeculoplaty, SLT)을 시행 받은 개방각녹내장 환자에서 치료받지 않은 반대안의 안압을 보정하여 SLT의 안압하강 효과 및 성공예측인자를 분석하고자 하였다.
      대상과 방법: 단안에 SLT를 시행 받고 1년 이상 관찰한 개방각녹내장 환자 52명 52안을 후향적으로 분석하였다. 시술 전, 시술 후 1, 2, 3개월, 이후 3개월마다 안압을 측정하였다. 시술 후 안압은 치료받지 않은 반대안의 안압변화량으로 보정하여 계산하였다. SLT의 성공은 시술 전 안압보다 20% 이상 감소한 경우로 정의하였다. Kaplan-Meier 생존분석을 이용하여 성공률을 산출하였고, 성공예측인자를 분석하였다.
      결과: 시술 전 평균 안압은 23.17 ± 6.96 mmHg, 시술 후 1년째 평균 안압하강은 5.59 ± 4.78 mmHg (29.7%)였으며, 반대안 안압을 보정한 안압하강은 4.70 ± 4.67 mmHg (23.9%)였다. SLT의 성공률은 65.4%, 반대안 안압을 보정한 성공률은 53.9%였다. 시술 전 안압만이 SLT 성공과 유의한 상관관계를 보였고, 시술 전 안압이 높을수록 시술 후 안압하강이 크게 나타났다(p=0.025). 나이와 시야검사의 mean deviation은 SLT 성공과 유의한 상관관계가 없었다(p=0.066, p=0.464).
      결론: 개방각녹내장 환자에서 SLT는 안전하고 효과적인 치료 방법이며, 시술 전 안압만이 SLT의 성공과 유의한 상관관계를 보였다. 정확한 치료 효과 분석을 위하여 반대안의 안압 변동을 고려하여야 하겠다.
      번역하기

      목적: 선택적 레이저섬유주성형술(selective laser trabeculoplaty, SLT)을 시행 받은 개방각녹내장 환자에서 치료받지 않은 반대안의 안압을 보정하여 SLT의 안압하강 효과 및 성공예측인자를 분석하...

      목적: 선택적 레이저섬유주성형술(selective laser trabeculoplaty, SLT)을 시행 받은 개방각녹내장 환자에서 치료받지 않은 반대안의 안압을 보정하여 SLT의 안압하강 효과 및 성공예측인자를 분석하고자 하였다.
      대상과 방법: 단안에 SLT를 시행 받고 1년 이상 관찰한 개방각녹내장 환자 52명 52안을 후향적으로 분석하였다. 시술 전, 시술 후 1, 2, 3개월, 이후 3개월마다 안압을 측정하였다. 시술 후 안압은 치료받지 않은 반대안의 안압변화량으로 보정하여 계산하였다. SLT의 성공은 시술 전 안압보다 20% 이상 감소한 경우로 정의하였다. Kaplan-Meier 생존분석을 이용하여 성공률을 산출하였고, 성공예측인자를 분석하였다.
      결과: 시술 전 평균 안압은 23.17 ± 6.96 mmHg, 시술 후 1년째 평균 안압하강은 5.59 ± 4.78 mmHg (29.7%)였으며, 반대안 안압을 보정한 안압하강은 4.70 ± 4.67 mmHg (23.9%)였다. SLT의 성공률은 65.4%, 반대안 안압을 보정한 성공률은 53.9%였다. 시술 전 안압만이 SLT 성공과 유의한 상관관계를 보였고, 시술 전 안압이 높을수록 시술 후 안압하강이 크게 나타났다(p=0.025). 나이와 시야검사의 mean deviation은 SLT 성공과 유의한 상관관계가 없었다(p=0.066, p=0.464).
      결론: 개방각녹내장 환자에서 SLT는 안전하고 효과적인 치료 방법이며, 시술 전 안압만이 SLT의 성공과 유의한 상관관계를 보였다. 정확한 치료 효과 분석을 위하여 반대안의 안압 변동을 고려하여야 하겠다.

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      참고문헌 (Reference)

      1 Heijl A, "reduction of intraocular pressure and glaucoma progression : results from the early manifest glaucoma trial" 120 : 1268-1279, 2002

      2 Damji KF, "Selective laser trabeculoplasty versus argon laser trabeculoplasty : results from a 1-year randomised clinical trial" 90 : 1490-1494, 2006

      3 Damji KF, "Selective laser trabeculoplasty v argon laser trabeculoplasty : a prospective randomised clinical trial" 83 : 718-722, 1999

      4 Koucheki B, "Selective laser trabeculoplasty in the treatment of open-angle glaucoma" 21 : 65-70, 2012

      5 Melamed S, "Selective laser trabeculoplasty as primary treatment for open-angle glaucoma: a prospective, nonrandomized pilot study" 121 : 957-960, 2003

      6 McIlraith I, "Selective laser trabeculoplasty as initial and adjunctive treatment for open-angle glaucoma" 15 : 124-130, 2006

      7 Latina MA, "Selective laser trabeculoplasty : stimulating the meshwork to mend its ways" 44 : 93-103, 2004

      8 Barkana Y, "Selective laser trabeculoplasty" 52 : 634-654, 2007

      9 Rozsival P, "Selective laser trabeculoplasty" 60 : 267-274, 2004

      10 Martow E, "SLT and adjunctive medical therapy : a prediction rule analysis" 20 : 266-270, 2011

      1 Heijl A, "reduction of intraocular pressure and glaucoma progression : results from the early manifest glaucoma trial" 120 : 1268-1279, 2002

      2 Damji KF, "Selective laser trabeculoplasty versus argon laser trabeculoplasty : results from a 1-year randomised clinical trial" 90 : 1490-1494, 2006

      3 Damji KF, "Selective laser trabeculoplasty v argon laser trabeculoplasty : a prospective randomised clinical trial" 83 : 718-722, 1999

      4 Koucheki B, "Selective laser trabeculoplasty in the treatment of open-angle glaucoma" 21 : 65-70, 2012

      5 Melamed S, "Selective laser trabeculoplasty as primary treatment for open-angle glaucoma: a prospective, nonrandomized pilot study" 121 : 957-960, 2003

      6 McIlraith I, "Selective laser trabeculoplasty as initial and adjunctive treatment for open-angle glaucoma" 15 : 124-130, 2006

      7 Latina MA, "Selective laser trabeculoplasty : stimulating the meshwork to mend its ways" 44 : 93-103, 2004

      8 Barkana Y, "Selective laser trabeculoplasty" 52 : 634-654, 2007

      9 Rozsival P, "Selective laser trabeculoplasty" 60 : 267-274, 2004

      10 Martow E, "SLT and adjunctive medical therapy : a prediction rule analysis" 20 : 266-270, 2011

      11 Kim JS, "Q-switched, frequency doubled Nd:YAG laser trabeculoplasty" 40 : 2591-2596, 1999

      12 Latina MA, "Q-switched 532-nm Nd:YAG laser trabeculoplasty (selective laser trabeculoplasty): a multicenter, pilot, clinical study" 105 : 2082-2088, 1998

      13 Lee JW, "Predictors of success in selective laser trabeculoplasty for primary open angle glaucoma in Chinese" 8 : 1787-1791, 2014

      14 Kim YJ, "One-year follow-up of laser trabeculoplasty using Q-switched frequency-doubled Nd : YAG laser of 523 nm wavelength" 31 : 394-399, 2000

      15 Stein JD, "Mechanisms of action and efficacy of argon laser trabeculoplasty and selective laser trabeculoplasty" 18 : 140-145, 2007

      16 Shazly TA, "Long-term safety and efficacy of selective laser trabeculoplasty as primary therapy for the treatment of pseudoexfoliation glaucoma compared with primary open-angle glaucoma" 5 : 5-10, 2010

      17 Medeiros FA, "Long-term intraocular pressure fluctuations and risk of conversion from ocular hypertension to glaucoma" 115 : 934-940, 2008

      18 Weinand FS, "Long-term clinical results of selective laser trabeculoplasty in the treatment of primary open angle glaucoma" 16 : 100-104, 2006

      19 Rachmiel R, "Laser trabeculoplasty trends with the introduction of new medical treatments and selective laser trabeculoplasty" 15 : 306-309, 2006

      20 Rhodes KM, "Intraocular pressure reduction in the untreated fellow eye after selective laser trabeculoplasty" 25 : 787-796, 2009

      21 Wilensky JT, "Individual variability in the diurnal intraocular pressure curve" 100 : 940-944, 1993

      22 Wakabayashi Y, "Improved prediction of fellow-eye response in one-eye trials using multiple intraocular pressure measurements" 55 : 480-485, 2011

      23 Song J, "High failure rate associated with 180degrees selective laser trabeculoplasty" 14 : 400-408, 2005

      24 Scherer WJ, "Effect of topical prostaglandin analog use on outcome following selective laser trabeculoplasty" 23 : 503-512, 2007

      25 Mao AJ, "Development of a prediction rule to estimate the probability of acceptable intraocular pressure reduction after selective laser trabeculoplasty in open-angle glaucoma and ocular hypertension" 17 : 449-454, 2008

      26 Kramer TR, "Comparison of the morphologic changes after selective laser trabeculoplasty and argon laser trabeculoplasty in human eye bank eyes" 108 : 773-779, 2001

      27 Juzych MS, "Comparison of long-term outcomes of selective laser trabeculoplasty versus argon laser trabeculoplasty in open-angle glaucoma" 111 : 1853-1859, 2004

      28 Kano K, "Clinical results of selective laser trabeculoplasty" 103 : 612-616, 1999

      29 Hodge WG, "Baseline IOP predicts selective laser trabeculoplasty success at 1 year post-treatment : results from a randomised clinical trial" 89 : 1157-1160, 2005

      30 Nagar M, "A randomised, prospective study comparing selective laser trabeculoplasty with latanoprost for the control of intraocular pressure in ocular hypertension and open angle glaucoma" 89 : 1413-1417, 2005

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      연월일 이력구분 이력상세 등재구분
      2023 평가예정 해외DB학술지평가 신청대상 (해외등재 학술지 평가)
      2020-01-01 평가 등재학술지 유지 (해외등재 학술지 평가) KCI등재
      2017-01-01 평가 등재학술지 유지 (계속평가) KCI등재
      2013-01-01 평가 등재 1차 FAIL (등재유지) KCI등재
      2010-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2007-01-01 평가 등재학술지 선정 (등재후보2차) KCI등재
      2006-01-01 평가 등재후보 1차 PASS (등재후보1차) KCI등재후보
      2005-01-01 평가 등재후보학술지 유지 (등재후보1차) KCI등재후보
      2003-01-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
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      학술지 인용정보
      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 0.22 0.22 0.22
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0.23 0.23 0.366 0.02
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