Objectives : The present study was to examine possible association between the - G308A tumor necrosis factor (TNF)-α gene polymorphism and major depressive disorder (MDD) in Korean.
Methods : 108 inpatients with MDD and 125 healthy controls particip...
Objectives : The present study was to examine possible association between the - G308A tumor necrosis factor (TNF)-α gene polymorphism and major depressive disorder (MDD) in Korean.
Methods : 108 inpatients with MDD and 125 healthy controls participated in this study. Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism.
Results : Genotype and allele distributions in patients with MDD (p=0.02, P=0.01, respectively), were significantly different from those of the controls.
Conclusion : The present study suggests that the -G308A TNF-α gene polymorphism may have a potential role for the susceptibility to MDD in Korean population.