흰쥐에 있어서 철분의 과량투여가 정소 및 혈장의 지질과 Vitamin E 함량 및 정소조직에 미치는 영향 = Effect of Iron - Overloading on Lipids and Vitamin E Content of Testes and Blood Plasma , and on Histological Changes of Testes in Rats

다국어 초록 (Multilingual Abstract)

The body weights of the iron-overloaded rats were gained more slowly than those of controlled rats (p $lt; 0.01). The contents of vitamin E, phospholipid, free unsaturated fatty acid, total cholesterol and free cholesterol of the testes of the iron-overloaded rats decreased significantly as compared with those of the controlled rats at 60 days of experiment (p $lt; 0.01). The cell membrane fragilities of erythrocytes from the iron-overloaded rats were higher than the mean value of the controlled rats (p $lt; 0.01). The iron-overloaded rats have a tendency to decrease in the contents of vitamin E and phospholipid in blood plasma. The plasma level of testosterone for injection group was lower as compared with that for the controlled group, but those of 1.3% and 2.6% Fe diet group increased. In terms of histology, irreversible testicular degeneration in rats occurs with iron-overloading, because of increase in oxidation reaction rate due to the decrease of vitamin E.