항경련제 투여 환아의 간기능 변화 = The Efficacy of Routine Liver Function Test in Epileptic Children

다국어 초록 (Multilingual Abstract)

Routine liver function test is done in epileptic children receiving antiepileptic drugs to prevent hepatotoxicity induced by these drugs. The abnormalities of liver function test are rarely seen, but these abnormalities accompanied by the clinical manifestation of hepatotoxicity are seldomly seen. This study carried out in order to assess the efficacy of routine liver function test in epileptic children.
We examed the changes of the serum level of aspartate transferase(AST), alanine aminotransferase(ALT), total bilirubin, total protein, albumine, alkaline phosphatase(ALP) before and after antiepileptic drug medication in 60 epileptic children who had been receiving valproic acid(n=25명), ethosuximide(n=6명), carbamazepine(n=4명), valproic acid and carbamazepine(n= 14명), and other polytherapy(n=11명) for 3months or more.
Results are as follows ;
1) The difference in each groups according to age, duration of treatment, and drug plasma concentration was not found.
2) AST was within normal range in any group, but decreased after valproic acid, ethosuximide, carbamazepine, and other polytherapy treatment.
3) ALT was within normal range in any group, but decreased after valproic acid treatment.
4) Total bilirubin, total protein, albumin, and ALP were within normal range in any groups.
5) Y-GT was within normal range, but the values were increasing tendency in polytherapy groups.
6) No clinical significant menifestations had developed during study period in any groups.
The result suggest that the routine liver function test itself can not be the indicator of hepatotoxicity, and that the liver function test exammed when the clinical symptoms appear is more effective than the routine liver function test.